This study reports the consequences of knocking out NADPH (nicotinamide adenine dinucleotide
phosphate) oxidase 4 (Nox4) on the development of hypertension and kidney injury in …

Renal T-cell infiltration is a key component of salt-sensitive hypertension in Dahl salt-sensitive
(SS) rats. Here, we use an electronic servo-control technique to determine the contribution …

Environmental exposure of parents or early in life may affect disease development in adults.
We found that hypertension and renal injury induced by a high-salt diet were substantially …

mTOR (mammalian target of rapamycin) signaling has emerged as a key regulator in a wide
range of cellular processes ranging from cell proliferation, immune responses, and …

Despite the striking differences between male and female physiology, female physiology is
understudied. In response, the National Institutes of Health is promulgating new policies to …

We have reported that a high-salt (4.0% NaCl) dietary intake activates mTORC1 and inhibition
of this pathway with rapamycin blunts the chronic phase of salt-induced hypertension and …

The goal of the present study was to explore the protective effects of mTORC1 (mammalian
target of rapamycin complex 1) inhibition by rapamycin on salt-induced hypertension and …

The present study examined the extent to which leukocyte infiltration into the kidneys in Ang
II (angiotensin II)-induced hypertension is determined by elevation of renal perfusion …

A 1.37 Mbp region of chromosome 13 previously identified by exclusion mapping was
consistently associated with a reduction of salt-induced hypertension in the Dahl salt-sensitive (SS…

Null mutations in the p67 phox subunit of nicotinamide adenine dinucleotide phosphate–oxidase
confer protection from salt sensitivity on Dahl salt-sensitive rats. Here, we track the …