Advanced, metastatic melanomas frequently grow in subcutaneous tissues and portend a
poor prognosis. Though subcutaneous tissues are largely composed of adipocytes, the …

Cellular plasticity is a state in which cancer cells exist along a reversible phenotypic spectrum,
and underlies key traits such as drug resistance and metastasis. Melanoma plasticity is …

INTRODUCTION Tumor analyses have shown that DNA mutations can transform cells in some
situations but not in others. In melanoma, BRAF V600E [serine/threonine-protein kinase B…

Oncogenic alterations to DNA are not transforming in all cellular contexts 1 , 2 . This may be
due to pre-existing transcriptional programmes in the cell of origin. Here we define anatomic …

The DNA polymerase Polκ plays a key role in translesion synthesis, an error-prone replication
mechanism. Polκ is overexpressed in various tumor types. Here, we found that melanoma …

In the last decade, zebrafish have accompanied the mouse as a robust animal model for
cancer research. The possibility of screening small-molecule inhibitors in a large number of …

Background Cancer genomes evolve in both space and time, which contributes to the genetic
heterogeneity that underlies tumor progression and drug resistance. In human melanoma, …

Cancer, a family of over a hundred disease varieties, is detected in 2 million people every
year, resulting in 600,000 deaths, in the US alone. Researchers and physicians have made …

OBJECTIVE—The ATP-binding cassette transporter A1 (ABCA1) R230C variant is
associated with low HDL cholesterol levels, obesity, and the metabolic syndrome in Mexican-Mestizos…

Although ATP-binding cassette transporter A1 (ABCA1) is well known for its role in cholesterol
efflux and HDL formation, it is expressed in various tissues, where it may have different …