β-Lactam antibiotics are the drugs of choice to treat pneumococcal infections. The spread of
β-lactam-resistant pneumococci is a major concern in choosing an effective therapy for …

Background Dental erosion is the dissolution of dental hard tissues caused by acids of a non‐bacterial
origin. Dietary acids are considered the predominant and most controllable factor. …

Inhibiting glycolysis remains an aspirational approach for the treatment of cancer. We have
previously identified a subset of cancers harbouring homozygous deletion of the glycolytic …

Background Genomic sequence-based deduction of antibiotic minimum inhibitory
concentration (MIC) has great potential to enhance the speed and sensitivity of antimicrobial …

Homozygous deletion of methylthioadenosine phosphorylase (MTAP) in cancers such as
glioblastoma represents a potentially targetable vulnerability. Homozygous MTAP-deleted cell …

Objective: Sinonasal undifferentiated carcinoma (SNUC) is a rare and aggressive malignancy
with optimal management remains unclear. We performed a review of the impact of …

We used whole-genome sequencing to characterize 199 nonvaccine serotype 35B pneumococcal
strains that caused invasive pneumococcal disease (IPD) in the United States during …

All known group A streptococci [GAS] are susceptible to β-lactam antibiotics. We recently
identified an invasive GAS (iGAS) variant (emm43.4/PBP2x-T553K) with unusually high …

Invasive pneumococcal disease (IPD) has greatly decreased since implementation in the
US of the 7 valent conjugate vaccine (PCV7) in 2000 and 13 valent conjugate vaccine (PCV13…

Importance Febrile infants at low risk of invasive bacterial infections are unlikely to benefit
from lumbar puncture, antibiotics, or hospitalization, yet these are commonly performed. It is …