[HTML][HTML] Reducing ventral tegmental dopamine D2 receptor expression selectively boosts incentive motivation

JW De Jong, TJM Roelofs, FMU Mol… - …, 2015 - nature.com
Altered mesolimbic dopamine signaling has been widely implicated in addictive behavior.
For the most part, this work has focused on dopamine within the striatum, but there is …

[HTML][HTML] A neuronal mechanism underlying decision-making deficits during hyperdopaminergic states

JPH Verharen, JW De Jong, TJM Roelofs… - Nature …, 2018 - nature.com
Hyperdopaminergic states in mental disorders are associated with disruptive deficits in
decision making. However, the precise contribution of topographically distinct mesencephalic …

A novel approach to map induced activation of neuronal networks using chemogenetics and functional neuroimaging in rats: A proof-of-concept study on the …

TJM Roelofs, JPH Verharen, GAF van Tilborg… - Neuroimage, 2017 - Elsevier
Linking neural circuit activation at whole-brain level to neuronal activity at cellular level
remains one of the major challenges in neuroscience research. We set up a novel functional …

[HTML][HTML] Distinct structure-function relationships across cortical regions and connectivity scales in the rat brain

M Straathof, MRT Sinke, TJM Roelofs, ELA Blezer… - Scientific reports, 2020 - nature.com
An improved understanding of the structure-function relationship in the brain is necessary to
know to what degree structural connectivity underpins abnormal functional connectivity …

[HTML][HTML] Optimization of whole-brain rabies virus tracing technology for small cell populations

TJM Roelofs, S Menting-Henry, LM Gol, AM Speel… - Scientific Reports, 2021 - nature.com
The lateral hypothalamus (LH) is critically involved in the regulation of homeostatic energy
balance. Some neurons in the LH express receptors for leptin (LepRb), a hormone known to …

Good taste or gut feeling? A new method in rats shows oro‐sensory stimulation and gastric distention generate distinct and overlapping brain activation patterns

TJM Roelofs, MCM Luijendijk… - … Journal of Eating …, 2021 - Wiley Online Library
Satiation is influenced by a variety of signals including gastric distention and oro‐sensory
stimulation. Here we developed a high‐field (9.4 T) functional magnetic resonance imaging (…

[HTML][HTML] Limbic control over the homeostatic need for sodium

JPH Verharen, TJM Roelofs, S Menting-Henry… - Scientific Reports, 2019 - nature.com
The homeostatic need for sodium is one of the strongest motivational drives known in animals.
Although the brain regions involved in the sensory detection of sodium levels have been …

Diet as connecting factor: Functional brain connectivity in relation to food intake and sucrose tasting, assessed with resting‐state functional MRI in rats

TJM Roelofs, M Straathof… - Journal of …, 2022 - Wiley Online Library
Eating disorders and obesity form a major health problem in Western Society. To be able to
provide adequate treatment and prevention, it is necessary to understand the neural …

[PDF][PDF] Distinct structure-function relationships across cortical regions and connectivity scales in the rat brain Running title: Structure-function relationships across rat …

M Straathof, MRT Sinke, TJM Roelofs, ELA Blezer… - researchgate.net
An improved understanding of the structure-function relationship in the brain is necessary to
know to what degree structural connectivity underpins abnormal functional connectivity …

Distinct structure-function relationships at different hierarchical levels of structural connectivity in the rat brain.

M Straathof, MRT Sinke, TJM Roelofs, ELA Blezer… - archive.ismrm.org
The relationship between functional and structural connectivity strength in the brain remains
uncertain. We compared high-field resting-state fMRI, diffusion-based tractography and …