Identification of new players in iron metabolism, such as hepcidin, which regulates
ferroportin and divalent metal transporter 1 expression, has improved our knowledge of iron …

The term hemochromatosis (HC) corresponds to several diseases characterized by systemic
iron overload of genetic origin and affecting both the quality of life and life expectancy. …

Genetic hemochromatosis is an iron overload disease that is mainly related to the C282Y
mutation in the HFE gene. This gene controls the expression of hepcidin, a peptide secreted in …

Bedridden patients in intensive care unit or after surgery intervention commonly develop
skeletal muscle weakness. The latter is promoted by a variety of prolonged hospitalization-…

Iron overload is one of the secondary osteoporosis etiologies. Cellular and molecular
mechanisms involved in iron‐related osteoporosis are not fully understood. Aim The aim of the …

New Findings What is the central question of this study? Although microgravity is well known
to reduce circulating iron in astronauts, the underlying mechanism is still unknown. We …

Hereditary aceruloplasminemia (HA), related to mutations in the ceruloplasmin (Cp) gene,
leads to iron accumulation. Ceruloplasmin ferroxidase activity being considered essential for …

Physical inactivity increases the risk to develop type 2 diabetes, a disease characterized by
a state of insulin resistance. By promoting inflammatory state, ceramides are especially …

Iron is reported to interact with other metals. In addition, it has been shown that genetic
background may impact iron metabolism. Our objective was to characterize, in mice of three …

Iron excess increases the hepatic expression of hepcidin, the systemic iron metabolism
regulator, that favors the iron sequestration in the spleen. Genetic iron overload related to …