Neovascularization of ischemic muscle may be sufficient to preserve tissue integrity and/or
function and may thus be considered to be therapeutic. The regulatory role of vascular …

Smooth muscle cells, macrophages, glial cells, keratinocytes, and transformed cells have
been established as synthesis sites for vascular endothelial growth factor (VEGF). The …

Balloon angioplasty disrupts the protective endothelial lining of the arterial wall, rendering
arteries susceptible to thrombosis and intimal thickening. We show here that vascular …

Blood flow produces mechanical frictional forces, parallel to the blood flow exerted on the
endothelial wall of the vessel, the so-called wall shear stress (WSS). WSS sensing is …

Background—The impact of disordered lipid metabolism on collateral vessel development
was studied in apolipoprotein (apo)E −/− mice with unilateral hindlimb ischemia. Methods and …

Background— FrzA/sFRP-1, a secreted, frizzled-related protein and antagonist for the wnt/frizzled
pathway, is expressed in the heart and vessels during mouse embryogenesis and …

Mesenchymal stem cells (MSC) are multipotent postnatal stem cells, involved in the
treatment of ischemic vascular diseases. We investigate the ability of MSC, exposed to short-term …

Background Because prior studies have established the critical role of the endothelium in
preventing vascular thrombosis and intimal thickening, we designed a series of experiments to …

Vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) is an endothelial-cell-specific
mitogen; as such, its role in angiogenesis has been studied extensively. VEGF/…

Vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1),
and E-selectin are inducible proteins involved in cell-cell adhesion. Immunohistochemical …