Quantifying cell behaviors in animal early embryogenesis remains a challenging issue
requiring in toto imaging and automated image analysis. We designed a framework for imaging …

Toxicity is one of the major attrition causes during the drug development process. In that line,
cardio-, neuro-, and hepatotoxicities are among the main reasons behind the retirement of …

The quantitative and systematic analysis of embryonic cell dynamics from in vivo 3D+ time
image data sets is a major challenge at the forefront of developmental biology. Despite recent …

Investigating neural stem cell (NSC) behaviour in vivo, which is a major area of research,
requires NSC models to be developed. We carried out a multilevel characterisation of the …

A gene expression atlas is an essential resource to quantify and understand the multiscale
processes of embryogenesis in time and space. The automated reconstruction of a prototypic …

10.7554/eLife.22268.001 Reconstructing the lineage of cells is central to understanding
how the wide diversity of cell types develops. Here, we provide the neurosensory lineage …

Tissue internalisation is a key morphogenetic mechanism by which embryonic tissues
generate complex internal organs and a number of studies of epithelia have outlined a general …

We conducted a quantitative comparison of developing sea urchin embryos based on the
analysis of five digital specimens obtained by automatic processing of in toto 3D+ time image …

We propose to directly process 3D+t image sequences with mathematical morphology
operators, using a new classification of the 3D+t structuring elements. Several methods (filtering, …

Investigating cell dynamics during early zebrafish embryogenesis requires specific image
acquisition and analysis strategies. Multiharmonic microscopy, ie, second- and third-harmonic …