[PDF][PDF] Reduced blood-stage malaria growth and immune correlates in humans following RH5 vaccination
…, NJ Brendish, Y Themistocleous, TA Rawlinson… - Med, 2021 - cell.com
Background Development of an effective vaccine against the pathogenic blood-stage infection
of human malaria has proved challenging, and no candidate vaccine has affected blood-…
of human malaria has proved challenging, and no candidate vaccine has affected blood-…
Vaccination with Plasmodium vivax Duffy-binding protein inhibits parasite growth during controlled human malaria infection
…, JR Barrett, Y Themistocleous, TA Rawlinson… - Science translational …, 2023 - science.org
There are no licensed vaccines against Plasmodium vivax. We conducted two phase 1/2a
clinical trials to assess two vaccines targeting P. vivax Duffy-binding protein region II (PvDBPII)…
clinical trials to assess two vaccines targeting P. vivax Duffy-binding protein region II (PvDBPII)…
[HTML][HTML] Human vaccination against Plasmodium vivax Duffy-binding protein induces strain-transcending antibodies
RO Payne, SE Silk, SC Elias, KH Milne, TA Rawlinson… - JCI insight, 2017 - ncbi.nlm.nih.gov
BACKGROUND. Plasmodium vivax is the most widespread human malaria geographically;
however, no effective vaccine exists. Red blood cell invasion by the P. vivax merozoite …
however, no effective vaccine exists. Red blood cell invasion by the P. vivax merozoite …
Rapid and iterative genome editing in the malaria parasite Plasmodium knowlesi provides new tools for P. vivax research
10.7554/eLife.45829.001 Tackling relapsing Plasmodium vivax and zoonotic Plasmodium
knowlesi infections is critical to reducing malaria incidence and mortality worldwide. …
knowlesi infections is critical to reducing malaria incidence and mortality worldwide. …
[HTML][HTML] Structural basis for inhibition of Plasmodium vivax invasion by a broadly neutralizing vaccine-induced human antibody
TA Rawlinson, NM Barber, F Mohring, JS Cho… - Nature …, 2019 - nature.com
The most widespread form of malaria is caused by Plasmodium vivax. To replicate, this
parasite must invade immature red blood cells through a process requiring interaction of the P. …
parasite must invade immature red blood cells through a process requiring interaction of the P. …
[HTML][HTML] Controlled human malaria infection with a clone of Plasmodium vivax with high-quality genome assembly
…, D Quinkert, CM Nielsen, NJ Edwards, TA Rawlinson… - JCI insight, 2021 - ncbi.nlm.nih.gov
Controlled human malaria infection (CHMI) provides a highly informative means to investigate
host-pathogen interactions and enable in vivo proof-of-concept efficacy testing of new …
host-pathogen interactions and enable in vivo proof-of-concept efficacy testing of new …
[PDF][PDF] A humanized mouse model for Plasmodium vivax to test interventions that block liver stage to blood stage transition and blood stage infection
…, N Kangwanrangsan, M Bardelli, TA Rawlinson… - IScience, 2020 - cell.com
The human malaria parasite Plasmodium vivax remains vastly understudied, mainly due to
the lack of suitable laboratory models. Here, we report a humanized mouse model to test …
the lack of suitable laboratory models. Here, we report a humanized mouse model to test …
[HTML][HTML] A systematic analysis of the human immune response to Plasmodium vivax
…, Y Themistocleous, TA Rawlinson… - The Journal of …, 2023 - Am Soc Clin Investig
BACKGROUND The biology of Plasmodium vivax is markedly different from that of P.
falciparum; how this shapes the immune response to infection remains unclear. To address this …
falciparum; how this shapes the immune response to infection remains unclear. To address this …
[HTML][HTML] Divergent roles for the RH5 complex components, CyRPA and RIPR in human-infective malaria parasites
…, KE Wright, S Kumar Prajapati, TA Rawlinson… - PLoS …, 2019 - journals.plos.org
Malaria is caused by Plasmodium parasites, which invade and replicate in erythrocytes. For
Plasmodium falciparum, the major cause of severe malaria in humans, a heterotrimeric …
Plasmodium falciparum, the major cause of severe malaria in humans, a heterotrimeric …
[HTML][HTML] Impact of a blood-stage vaccine on Plasmodium vivax malaria
MM Hou, JR Barrett, Y Themistocleous, TA Rawlinson… - MedRxiv, 2022 - ncbi.nlm.nih.gov
Background: There are no licensed vaccines against Plasmodium vivax, the most common
cause of malaria outside of Africa. Methods: We conducted two Phase I/IIa clinical trials to …
cause of malaria outside of Africa. Methods: We conducted two Phase I/IIa clinical trials to …