User profiles for Thomas Bjarnsholt

Thomas Bjarnsholt

Professor in Biofilms and Chronic Infections
Verified email at sund.ku.dk
Cited by 34485

The in vivo biofilm

T Bjarnsholt, M Alhede, M Alhede… - Trends in …, 2013 - cell.com
Bacteria can grow and proliferate either as single, independent cells or organized in aggregates
commonly referred to as biofilms. When bacteria succeed in forming a biofilm within the …

Pseudomonas aeruginosa biofilms in the respiratory tract of cystic fibrosis patients

T Bjarnsholt, PØ Jensen, MJ Fiandaca… - Pediatric …, 2009 - Wiley Online Library
The present study was undertaken to investigate the appearance and location of Pseudomonas
aeruginosa in the cystic fibrosis (CF) lung and in sputum. Samples include preserved …

Antibiotic resistance of bacterial biofilms

N Høiby, T Bjarnsholt, M Givskov, S Molin… - International journal of …, 2010 - Elsevier
A biofilm is a structured consortium of bacteria embedded in a self-produced polymer matrix
consisting of polysaccharide, protein and DNA. Bacterial biofilms cause chronic infections …

The role of bacterial biofilms in chronic infections

T Bjarnsholt - Apmis, 2013 - Wiley Online Library
Acute infections caused by pathogenic bacteria have been studied extensively for well over
100 years. These infections killed millions of people in previous centuries, but they have …

The biofilm life cycle: expanding the conceptual model of biofilm formation

…, M Burmølle, PS Stewart, T Bjarnsholt - Nature Reviews …, 2022 - nature.com
Bacterial biofilms are often defined as communities of surface-attached bacteria and are
typically depicted with a classic mushroom-shaped structure characteristic of Pseudomonas …

Why chronic wounds will not heal: a novel hypothesis

T Bjarnsholt, K Kirketerp‐Møller… - Wound repair and …, 2008 - Wiley Online Library
The present paper presents a hypothesis aimed at explaining why venous leg ulcers, pressure
ulcers, and diabetic foot ulcers develop into a chronic state. We propose that the lack of …

The clinical impact of bacterial biofilms

…, M Givskov, T Tolker‐Nielsen, T Bjarnsholt - International journal of …, 2011 - nature.com
Bacteria survive in nature by forming biofilms on surfaces and probably most, if not all,
bacteria (and fungi) are capable of forming biofilms. A biofilm is a structured consortium of …

Screening for quorum-sensing inhibitors (QSI) by use of a novel genetic system, the QSI selector

TB Rasmussen, T Bjarnsholt, ME Skindersoe… - Journal of …, 2005 - Am Soc Microbiol
With the widespread appearance of antibiotic-resistant bacteria, there is an increasing demand
for novel strategies to control infectious diseases. Furthermore, it has become apparent …

Pseudomonas aeruginosa biofilms in cystic fibrosis

N Høiby, O Ciofu, T Bjarnsholt - Future microbiology, 2010 - Future Medicine
The persistence of chronic Pseudomonas aeruginosa lung infections in cystic fibrosis (CF)
patients is due to biofilm-growing mucoid (alginate-producing) strains. A biofilm is a structured …

Identity and effects of quorum-sensing inhibitors produced by Penicillium species

TB Rasmussen, ME Skindersoe, T Bjarnsholt… - …, 2005 - microbiologyresearch.org
Quorum sensing (QS) communication systems are thought to afford bacteria with a mechanism
to strategically cause disease. One example is Pseudomonas aeruginosa, which infects …