The fibrous collagens are ubiquitous in animals and form the structural basis of all mammalian
connective tissues, including those of the heart, vasculature, skin, cornea, bones, and …

The passive tension-sarcomere length relation of rat cardiac muscle was investigated by
studying passive (or not activated) single myocytes and trabeculae. The contribution of collagen…

Background: The proteins belonging to the collagen family are ubiquitous throughout the
animal kingdom. The most abundant collagen, type I, readily forms fibrils that convey the …

Skeletal muscle can bear a high load at constant length, or shorten rapidly when the load is
low. This force-velocity relationship is the primary determinant of muscle performance in vivo…

The Frank–Starling law of the heart describes the interrelationship between end-diastolic
volume and cardiac ejection volume, a regulatory system that operates on a beat-to-beat basis. …

Mutations in β-cardiac myosin, the predominant motor protein for human heart contraction,
can alter power output and cause cardiomyopathy. However, measurements of the intrinsic …

We studied the effect of titin-based passive force on the length dependence of activation of
cardiac myocytes to explore whether titin may play a role in the generation of systolic force. …

Elastin enables the reversible deformation of elastic tissues and can withstand decades of
repetitive forces. Tropoelastin is the soluble precursor to elastin, the main elastic protein found …

The Frank–Starling mechanism of the heart is due, in part, to modulation of myofilament Ca
2+ sensitivity by sarcomere length (SL) [length-dependent activation (LDA)]. The molecular …

Phosphorylation of myosin regulatory light chain (RLC) by myosin light chain kinase (MLCK)
and myosin binding protein‐C (cMyBP‐C) by protein kinase A (PKA) independently …