User profiles for Thomas Childs

Thomas Childs

University College London
Verified email at ucl.ac.uk
Cited by 98

[BOOK][B] Metal machining: theory and applications

THC Childs - 2000 - books.google.com
Metal machining is the most widespread metal-shaping process in the mechanical manufacturing
industry. World-wide investment in metal machining tools increases year on year-and …

[HTML][HTML] Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer's disease

…, J Rueda-Carrasco, SH Shin, JS Kim, T Childs… - Nature …, 2023 - nature.com
Alzheimer’s disease (AD) is characterized by synaptic loss, which can result from
dysfunctional microglial phagocytosis and complement activation. However, what signals drive …

[HTML][HTML] Clinical validation of cutoff target ranges in newborn screening of metabolic disorders by tandem mass spectrometry: a worldwide collaborative project

…, AC Ramos, D Cheillan, YH Chien, TA Childs… - Genetics in …, 2011 - nature.com
Purpose: To achieve clinical validation of cutoff values for newborn screening by tandem mass
spectrometry through a worldwide collaborative effort. Methods: Cumulative percentiles of …

Minimising Embodied Product Energy to support energy efficient manufacturing

S Rahimifard, Y Seow, T Childs - CIRP annals, 2010 - Elsevier
Green sources of power generation and efficient management of energy demand are among
the greatest challenges facing manufacturing businesses. A significant proportion of energy …

GSK-3β negatively regulates skeletal myotube hypertrophy

…, TW Abraha, TE Childs… - … of Physiology-Cell …, 2002 - journals.physiology.org
To determine whether changes in glycogen synthase kinase-3β (GSK-3β) phosphorylation
contribute to muscle hypertrophy, we delineated the effects of GSK-3β activity on C 2 C 12 …

Microglia‐synapse engulfment via PtdSer‐TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models

…, D Sokolova, SE Lee, T Childs… - The EMBO …, 2023 - embopress.org
Neuronal hyperactivity is a key feature of early stages of Alzheimer's disease (AD). Genetic
studies in AD support that microglia act as potential cellular drivers of disease risk, but the …

[HTML][HTML] Enhanced interpretation of newborn screening results without analyte cutoff values

…, M Sierra, YH Chien, WL Hwu, T Childs… - Genetics in …, 2012 - nature.com
Purpose: To improve quality of newborn screening by tandem mass spectrometry with a novel
approach made possible by the collaboration of 154 laboratories in 49 countries. Methods…

Temporal alterations in protein signaling cascades during recovery from muscle atrophy

TE Childs, EE Spangenburg… - American Journal of …, 2003 - journals.physiology.org
Currently, the repertoire of cellular and molecular pathways that control skeletal muscle atrophy
and hypertrophy are not well defined. It is possible that intracellular regulatory signaling …

Exploring relationships between touch perception and surface physical properties

…, F Shao, CJ Barnes, T Childs… - … Journal of Design, 2009 - eprints.leedsbeckett.ac.uk
This paper reports a study of materials for confectionery packaging. The aim was to explore
the touch perceptions of textures and identify their relationships with the surfaces' physical …

Dopamine D1 receptor modulation in nucleus accumbens lowers voluntary wheel running in rats bred to run high distances

MD Roberts, L Gilpin, KE Parker, TE Childs, MJ Will… - Physiology & …, 2012 - Elsevier
Dopamine signaling in the nucleus accumbens (NAc) has been postulated to influence reward
development towards drugs of abuse and exercise. Herein, we used generation 4–5 rats …