User profiles for Thomas D. Mrsic-Flogel

Thomas Mrsic-Flogel

Sainsbury Wellcome Centre, University College London
Verified email at ucl.ac.uk
Cited by 10744

The emergence of functional microcircuits in visual cortex

…, J Antolik, C Clopath, SB Hofer, TD Mrsic-Flogel - Nature, 2013 - nature.com
… the centre of the monitor is at (0, 0, d) (where d is the shortest distance to the mouse eye from
the … of the Mrsic-Flogel laboratory for advice and comments on the manuscript. We thank D. …

Functional specificity of local synaptic connections in neocortical networks

…, B Pichler, KA Buchanan, PJ Sjöström, TD Mrsic-Flogel - Nature, 2011 - nature.com
Neuronal connectivity is fundamental to information processing in the brain. Therefore,
understanding the mechanisms of sensory processing requires uncovering how connection …

Cortical connectivity and sensory coding

KD Harris, TD Mrsic-Flogel - Nature, 2013 - nature.com
The sensory cortex contains a wide array of neuronal types, which are connected together
into complex but partially stereotyped circuits. Sensory stimuli trigger cascades of electrical …

Differential connectivity and response dynamics of excitatory and inhibitory neurons in visual cortex

…, H Zeng, E Lein, NA Lesica, TD Mrsic-Flogel - Nature …, 2011 - nature.com
Neuronal responses during sensory processing are influenced by both the organization of
intracortical connections and the statistical features of sensory stimuli. How these intrinsic and …

A genetically encoded calcium indicator for chronic in vivo two-photon imaging

M Mank, AF Santos, S Direnberger, TD Mrsic-Flogel… - Nature …, 2008 - nature.com
Neurons in the nervous system can change their functional properties over time. At present,
there are no techniques that allow reliable monitoring of changes within identified neurons …

Experience leaves a lasting structural trace in cortical circuits

SB Hofer, TD Mrsic-Flogel, T Bonhoeffer, M Hübener - Nature, 2009 - nature.com
Sensory experiences exert a powerful influence on the function and future performance of
neuronal circuits in the mammalian neocortex 1 , 2 , 3 . Restructuring of synaptic connections …

[PDF][PDF] Predictive processing: a canonical cortical computation

GB Keller, TD Mrsic-Flogel - Neuron, 2018 - cell.com
This perspective describes predictive processing as a computational framework for
understanding cortical function in the context of emerging evidence, with a focus on sensory …

Functional organization of excitatory synaptic strength in primary visual cortex

…, R Houlton, EN Sader, H Ko, SB Hofer, TD Mrsic-Flogel - Nature, 2015 - nature.com
The strength of synaptic connections fundamentally determines how neurons influence each
other’s firing. Excitatory connection amplitudes between pairs of cortical neurons vary over …

Diverse coupling of neurons to populations in sensory cortex

…, H Ko, P Barthó, T Moore, SB Hofer, TD Mrsic-Flogel… - Nature, 2015 - nature.com
A large population of neurons can, in principle, produce an astronomical number of distinct
firing patterns. In cortex, however, these patterns lie in a space of lower dimension 1 , 2 , 3 , 4 …

[PDF][PDF] Learning enhances sensory and multiple non-sensory representations in primary visual cortex

…, M Bauza, M Sahani, GB Keller, TD Mrsic-Flogel… - Neuron, 2015 - cell.com
We determined how learning modifies neural representations in primary visual cortex (V1)
during acquisition of a visually guided behavioral task. We imaged the activity of the same …