Cells use feedback regulation to ensure robust growth despite fluctuating demands for
resources and differing environmental conditions. However, the expression of foreign proteins …

High‐resolution monitoring is fundamental to understand ecosystems dynamics in an era of
global change and biodiversity declines. While real‐time and automated monitoring of …

Complex networked systems abound in Nature and Technology. They consist of a multitude
of interacting agents communicating with each other over a web of complex interconnections…

Large-scale collective behaviors such as synchronization and coordination spontaneously
arise in many bacterial populations. With systems biology attempting to understand these …

Translation of protein from mRNA is a complex multi-step process that occurs at a non-uniform
rate. Variability in ribosome speed along an mRNA enables refinement of the proteome …

Synthetic biology uses living cells as the substrate for performing human-defined computations.
Many current implementations of cellular computing are based on the “genetic circuit” …

Cells contain a finite set of resources that must be distributed across many processes to ensure
survival. Among them, the largest proportion of cellular resources is dedicated to protein …

Biological systems exhibit complex behaviours that emerge at many different levels of
organization. These span the regulation of gene expression within single cells to the use of …

Genetic circuits implement computational operations within a cell. Debugging them is difficult
because their function is defined by multiple states (eg, combinations of inputs) that vary in …

Biological technologies are fundamentally unlike any other because biology evolves.
Bioengineering therefore requires novel design methodologies with evolution at their core. …