10.7554/eLife.36306.001 We investigated the role of full-length Drosophila Bicaudal D (BicD)
binding partners in dynein-dynactin activation for mRNA transport on microtubules. Full-…

Myosin-II (Myo2p) and tropomyosin are essential for contractile ring formation and
cytokinesis in fission yeast. Here we used a combination of in vivo and in vitro approaches to …

The protist parasite Trypanosoma brucei is an obligate extracellular pathogen that retains
its highly polarized morphology during cell division and has evolved a novel cytokinetic …

Many single-celled eukaryotes have complex cell morphologies defined by microtubules
arranged into higher-order structures. The auger-like shape of the parasitic protist …

Myosin V is an actin-based motor protein involved in intracellular cargo transport [1]. Given
this physiological role, it was widely assumed that all class V myosins are processive, able to …

Microtubules are inherently dynamic cytoskeletal polymers whose length and organization
can be altered to perform essential functions in eukaryotic cells, such as providing tracks for …

Molecular motors are instrumental in mRNA localization, which provides spatial and temporal
control of protein expression and function. To obtain mechanistic insight into how a class V …

We investigated the role of regulatory light-chain (Rlc1p) and heavy-chain phosphorylation
in controlling fission yeast myosin-II (Myo2p) motor activity and function during cytokinesis. …

The cytoskeletal protein actin plays a critical role in the pathogenicity of the intracellular
parasite, Toxoplasma gondii, mediating invasion and egress, cargo transport, and organelle …

Two functions are proposed for the conserved family of UCS proteins: helping to fold myosin
motor proteins and stimulating the motor function of folded myosins. We examined both …