MicroRNAs (miRNAs) play an important role in gene regulatory networks in animals. Yet,
the mechanistic details of their function in translation inhibition or messenger RNA (mRNA) …

MicroRNAs (miRNAs) inhibit mRNA expression in general by base pairing to the 3′UTR of
target mRNAs and consequently inhibiting translation and/or initiating poly(A) tail …

Dicer is central to microRNA-mediated silencing and several other RNA interference phenomena
that are profoundly embedded in cancer gene networks. Most recently, both germline …

In plants, animals, and fungi, members of the Dicer family of RNase III-related enzymes
process double-stranded RNA (dsRNA) to initiate small-RNA-mediated gene-silencing …

miRNAs recruit the miRNA-induced silencing complex (miRISC), which includes Argonaute
and GW182 as core proteins. GW182 proteins effect translational repression and …

Small regulatory RNAs are key regulators of gene expression. One class of small regulatory
RNAs, termed the endogenous small interfering RNAs (endo siRNAs), is thought to …

Argonaute (AGO) proteins interact with distinct classes of small RNAs to direct multiple
regulatory outcomes. In many organisms, including plants, fungi, and nematodes, cellular RNA-…

Human embryonic stem cells (hESCs) readily differentiate to somatic or germ lineages but
have impaired ability to form extra-embryonic lineages such as placenta or yolk sac. Here, we …

MicroRNAs (miRNAs) play critical roles in a variety of biological processes through
widespread effects on protein synthesis. Upon association with the miRNA-induced silencing …

Mammalian Staufen2 (Stau2) is involved in mRNA transport in neurons. Here,we report that
Stau2 is a double-stranded RNA-binding protein that is mainly expressed in the brain. We …