The isolation of morphine (‘principium somniferum’) by Friedrich Wilhelm Sertürner about
200 years ago is generally accepted as the beginning of scientific phytochemistry (plant …

Cullin proteins are molecular scaffolds that have crucial roles in the post-translational modification
of cellular proteins involving ubiquitin. The mammalian cullin protein family comprises …

Angiopoietin-2 (Ang2) exhibits broad expression in the remodeling vasculature of human
tumors but very limited expression in normal tissues, making it an attractive candidate target for …

Tinnitus is defined by an auditory perception in the absence of an external source of sound.
This condition provides the distinctive possibility of extracting neural coding of perceptual …

A broad consensus within the neuroscience of tinnitus holds that this audiologic condition is
triggered by central deafferentation, mostly due to cochlear damage. The absence of …

In his textbook published 125 years ago, Julius Sachs, one of the pioneers of plant
physiology, made a clear distinction between products of secondary metabolism ('Nebenprodukte …

As in other classes of natural products the number of new pyrrolizidine alkaloids (PAs) has
increased dramatically during the past decades. The first review by Leonard in 1950 [4] …

Like the visual and the sensorimotor systems, the auditory system exhibits pronounced
alpha-like resting oscillatory activity. Due to the relatively small spatial extent of auditory cortical …

Based upon a brief historical view, the typical features of plant secondary metabolism and
its role in chemical interactions between plants and their environment are discussed. Facts …

Background Subjective tinnitus is characterized by an auditory phantom perception in the
absence of any physical sound source. Consequently, in a quiet environment, tinnitus patients …