Resistance to DNA-damaging agents is a significant cause of treatment failure and poor
outcomes in oncology. To identify unrecognized regulators of cell survival we performed a whole…

The innate immune system is our first line of defense against viral pathogens. Host cell
pattern recognition receptors sense viral components and initiate immune signaling cascades …

Background The mammalian target of rapamycin (mTOR) has been suggested as a target for
radiosensitization. Given that radiotherapy is a primary treatment modality for glioblastoma (…

Cell surface innate immune receptors can directly detect a variety of extracellular pathogens
to which cytoplasmic innate immune sensors are rarely exposed. Instead, within the …

Background HPV infection is associated with high p16 expression and good prognosis in
head and neck squamous cell carcinomas (HNSCCs). Analysis of CDKN2A, the gene …

Purpose: Radiotherapy remains a primary treatment modality for pancreatic carcinoma, a
tumor characterized by aberrant mTOR activity. Given the regulatory role of mTOR in gene …

A core component in the cellular response to radiation occurs at the level of translational
control of gene expression. Because a critical element in translation control is the availability of …

Asparagine (N)–linked glycosylation is required for endoplasmic reticulum (ER) homeostasis,
but how this co- and posttranslational modification is maintained during ER stress is …

The Gene Ontology (GO) knowledgebase ( http://geneontology.org ) is a comprehensive
resource concerning the functions of genes and gene products (proteins and noncoding RNAs). …

Maintenance of genomic integrity is crucial for cell survival. As such, elegant DNA damage
response (DDR) systems have evolved to ensure proper repair of DNA double-strand breaks (…