Elucidating the cellular architecture of the human cerebral cortex is central to understanding
our cognitive abilities and susceptibility to disease. Here we used single-nucleus RNA-…

The primary motor cortex (M1) is essential for voluntary fine-motor control and is functionally
conserved across mammals 1 . Here, using high-throughput transcriptomic and epigenomic …

Progressive Visual Analytics aims at improving the interactivity in existing analytics techniques
by means of visualization as well as interaction with intermediate results. One key method …

Mass cytometry allows high-resolution dissection of the cellular composition of the immune
system. However, the high-dimensionality, large size, and non-linear structure of the data …

Deep neural networks are now rivaling human accuracy in several pattern recognition
problems. Compared to traditional classifiers, where features are handcrafted, neural networks …

In recent years, dimensionality‐reduction techniques have been developed and are widely
used for hypothesis generation in Exploratory Data Analysis. However, these techniques are …

Brain iron accumulation has been found to accelerate disease progression in amyloid-β(Aβ)
positive Alzheimer patients, though the mechanism is still unknown. Microglia have been …

Inflammatory intestinal diseases are characterized by abnormal immune responses and affect
distinct locations of the gastrointestinal tract. Although the role of several immune subsets …

To understand how the immune system works, one needs to have a clear picture of its cellular
compositon and the cells' corresponding properties and functionality. Mass cytometry is a …

The cognitive abilities of humans are distinctive among primates, but their molecular and
cellular substrates are poorly understood. We used comparative single-nucleus transcriptomics …