Superoxide dismutases are an ubiquitous family of enzymes that function to efficiently
catalyze the dismutation of superoxide anions. Three unique and highly compartmentalized …

Rationale: Airway inflammation is common in severe asthma despite antiinflammatory
therapy with corticosteroids. Lipoxin A 4 (LXA 4 ) is an arachidonic acid–derived mediator that …

Deletion of self-antigen-specific T cells during thymic development provides protection from
autoimmunity. However, it is unclear how efficiently this occurs for tissue-restricted self …

Chronic obstructive pulmonary disease (COPD) is a complex human disease likely influenced
by multiple genes, cigarette smoking, and gene-by-smoking interactions, but only severe …

Maternal immune responses can promote allergy development in offspring, as shown in a
model of increased susceptibility to asthma in babies of ovalbumin (OVA)-sensitized and -…

BACKGROUND: Although inhaled corticosteroids (ICSs) generally protect against severe
exacerbations in asthma, they may result in elevated IgE levels, which are associated with …

The National Heart, Lung, and Blood Institute is funding an effort to create a molecular atlas
of the developing lung (LungMAP) to serve as a research resource and public education tool…

Background While acute lung injury (ALI) contributes significantly to critical illness, it
resolves spontaneously in many instances. The majority of patients experiencing ALI require …

The STAT3 transcription factor is critical for cytokine signaling and the acute phase response,
but its role in allergic asthma is largely undefined. To investigate the role of STAT3 in …

Exposure to cigarette smoke (CS) is the primary factor associated with the development of
chronic obstructive pulmonary disease (COPD). CS increases the level of oxidants in the lungs…