[HTML][HTML] Proteomics approaches for biomarker and drug target discovery in ALS and FTD

TJ Hedl, R San Gil, F Cheng, SL Rayner… - Frontiers in …, 2019 - frontiersin.org
Neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS) and frontotemporal
dementia (FTD) are increasing in prevalence but lack targeted therapeutics. Although the …

[HTML][HTML] Unbiased Label-Free Quantitative Proteomics of Cells Expressing Amyotrophic Lateral Sclerosis (ALS) Mutations in CCNF Reveals Activation of the …

…, H Suddull, TR Chapman, TJ Hedl… - Frontiers in Molecular …, 2021 - frontiersin.org
The past decade has seen a rapid acceleration in the discovery of new genetic causes of
ALS, with more than 20 putative ALS-causing genes now cited. These genes encode proteins …

Riluzole does not ameliorate disease caused by cytoplasmic TDP‐43 in a mouse model of amyotrophic lateral sclerosis

…, KR Jacobs, H Gul, R San Gil, TJ Hedl… - European Journal of …, 2021 - Wiley Online Library
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease commonly treated with
riluzole, a small molecule that may act via modulation of glutamatergic neurotransmission. …

Riluzole does not ameliorate disease caused by cytoplasmic TDP-43 in a mouse model of amyotrophic lateral sclerosis

…, P Mehta, KR Jacobs, H Gul, RS Gil, TJ Hedl… - bioRxiv, 2019 - biorxiv.org
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease commonly treated with
riluzole, a small molecule that may act via modulation of glutamatergic neurotransmission. …

The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans

…, D Tidwell, E Lo, M Salvatore, S Shad, JA Thomas… - Science, 2015 - science.org
Understanding the functional consequences of genetic variation, and how it affects complex
human disease and quantitative traits, remains a critical challenge for biomedicine. We …

Proteomic characterisation of TDP-43 inclusion pathology in amyotrophic lateral sclerosis and frontotemporal dementia

TJ Hedl - 2022 - figshare.mq.edu.au
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are part of a spectrum
of adult-onset fatal neurodegenerative diseases. ALS begins in either the upper motor …

Smart shoppers tours: outcome evaluation

JAS Carson, JJ Hedl - Journal of nutrition education, 1998 - Elsevier
Smart Shoppers Tours were offered to mothers on limited incomes in southeast Dallas in
1995–96. Based on focus group data and the Food Guide Pyramid, the series of three tours …

Sub-barrier fusion of the oxygen isotopes: A more complete picture

J Thomas, YT Chen, S Hinds, D Meredith, M Olson - Physical Review C, 1986 - APS
We have measured the sub-barrier fusion cross sections for 16, 17, 18O on O 16 and we
present the data and the experimental method in detail. The data were analyzed with a one-…

Depression and test anxiety in comprehension and memory: Independent effects?

JJ Hedl, JC Bartlett - Cross Cultural Anxiety, 2018 - taylorfrancis.com
… Some prior experiments we have done in the test anxiety area (Hedl & Bartlett, 1981, 1982,
1985, 1989) have corroborated the importance of comprehension processes for inference-…

[HTML][HTML] LACC1 regulates TNF and IL-17 in mouse models of arthritis and inflammation

…, X Wu, M Sagolla, N Ota, A Wuster, J Tom… - The Journal of …, 2019 - journals.aai.org
Both common and rare genetic variants of laccase domain-containing 1 (LACC1, previously
C13orf31) are associated with inflammatory bowel disease, leprosy, Behcet disease, and …