We report a comprehensive toolkit that enables targeted, specific modification of monocot
and dicot genomes using a variety of genome engineering approaches. Our reagents, based …

The CRISPR/Cas9 system is rapidly becoming the reagent of choice for targeted mutagenesis
and gene editing in crop species. There are currently intense research efforts in the crop …

Understanding the molecular basis of repeatedly evolved phenotypes can yield key insights
into the evolutionary process. Quantifying gene flow between populations is especially …

Background Maize stover is an important source of crop residues and a promising sustainable
energy source in the United States. Stalk is the main component of stover, representing …

The ability to access alleles from unadapted germplasm collections is a long-standing problem
for geneticists and breeders. Here we developed, characterized, and demonstrated the …

Populations continually incur new mutations with fitness effects ranging from lethal to adaptive.
While the distribution of fitness effects of new mutations is not directly observable, many …

Background The safety of mutagenized and genetically transformed plants remains a subject
of scrutiny. Data gathered and communicated on the phenotypic and molecular variation …

Drug-evoked adaptations in the mesolimbic dopamine system are postulated to drive opioid
abuse and addiction. These adaptations vary in magnitude and direction following different …

Natural populations across a species range demonstrate population structure owing to neutral
processes such as localized origins of mutations and migration limitations. Selection also …

Recent advances in genome resequencing have led to increased interest in prediction of the
functional consequences of genetic variants. Variants at phylogenetically conserved sites …