Genome-wide association studies have identified thousands of loci for common diseases,
but, for the majority of these, the mechanisms underlying disease susceptibility remain …

The genetic architecture of autism spectrum disorder involves the interplay of common and
rare variants and their impact on hundreds of genes. Using exome sequencing, here we …

Investigation of the aetiology of Behçet's disease (BD) has focused predominantly on herpes
simplex virus immunopathology, autoimmunity to oral mucosa or cross-reactive microbial …

Four transgenic Nicotiana tabacum plants were generated that expressed a murine monoclonal
antibody kappa chain, a hybrid immunoglobulin AG heavy chain, a murine joining chain, …

The negotiations on the reforms of the Economic and Monetary Union were highly conflictual.
This article analyses the dimensions of conflict that structured these negotiations. Using …

Context Substantial resources are being devoted to identify candidate genes for complex
mental and behavioral disorders through inclusion of environmental exposures following the …

A functional comparison was made between a monoclonal secretory antibody generated in
transgenic plants and its parent murine IgC antibody .The affinity constants of both …

Shamil Sunyaev and colleagues present exome sequencing methods and their applications
in studies to identify the genetic basis of human complex traits. They include analyses of the …

Twin, adoption, and family studies have established the heritability of suicide attempts and
suicide. Identifying specific suicide diathesis-related genes has proven more difficult. As with …

Recent research on disparate psychiatric disorders has implicated rare variants in genes
involved in global gene regulation and chromatin modification, as well as many common …