Post-transcriptional modification of RNA nucleosides occurs in all living organisms.
Pseudouridine, the most abundant modified nucleoside in non-coding RNAs 1 , enhances the …

In budding yeast, key meiotic events such as DNA replication, recombination, and the
meiotic divisions are controlled by Clb cyclin-dependent kinases (Clb-CDKs). Using a novel …

Chronic obstructive pulmonary disease and pulmonary fibrosis have been hypothesized to
represent premature aging phenotypes. At times, they cluster in families, but the genetic basis …

Message-specific translational control is required for gametogenesis. In yeast, the RNA-binding
protein Rim4 mediates translational repression of numerous mRNAs, including the B-…

Pseudouridine (Ψ) is a post-transcriptional RNA modification that alters RNA–RNA and RNA–protein
interactions that affect gene expression. Messenger RNA pseudouridylation was …

Herpes simplex virus-1 (HSV-1) encephalitis (HSE) is typically sporadic. Inborn errors of
TLR3- and DBR1-mediated central nervous system cell-intrinsic immunity can account for …

Aneuploidy, a chromosome content that is not a multiple of the haploid karyotype, is
associated with reduced fitness in all organisms analyzed to date. In budding yeast aneuploidy …

Autoantibodies are a hallmark of numerous neurological disorders, including multiple
sclerosis, autoimmune encephalitides and neuromyelitis optica. Whilst well understood in …

Microglia are central nervous system (CNS) resident immune cells that have been implicated
in neuroinflammatory pathogenesis of a variety of neurological conditions. Their manifold …

RNA molecules contain a variety of chemically diverse, posttranscriptionally modified bases.
The most abundant modified base found in cellular RNAs, pseudouridine (Ψ), has recently …