Identifying individuals with hereditary syndromes allows for improved cancer surveillance,
risk reduction, and optimized management. Establishing criteria for assessment allows for the …

Longitudinal analysis of circulating tumor DNA (ctDNA) has shown promise for monitoring
treatment response. However, most current methods lack adequate sensitivity for residual …

Importance Guidelines for clinical management in Li-Fraumeni syndrome, a multiple-organ
cancer predisposition condition, are limited. Whole-body magnetic resonance imaging (…

Understanding the gene-specific risks for development of breast cancer will lead to improved
clinical care for those carrying germline mutations in cancer predisposition genes. We …

Circulating tumor DNA holds substantial promise as an early detection biomarker, particularly
for cancers that do not have currently accepted screening methodologies, such as ovarian, …

The variant curation guidelines published in 2015 by the American College of Medical Genetics
and Genomics and the Association for Molecular Pathology (ACMG/AMP) provided the …

Germline pathogenic variants in TP53 are associated with Li‐Fraumeni syndrome, a cancer
predisposition disorder inherited in an autosomal dominant pattern associated with a high …

The NCCN Guidelines for Colorectal Cancer (CRC) Screening outline various screening
modalities as well as recommended screening strategies for individuals at average or increased…

The NCCN Guidelines for Genetic/Familial High-Risk Assessment: Colorectal provide
recommendations for the management of patients with high-risk syndromes associated with an …

Sequencing tests assaying panels of genes or whole exomes are widely available for cancer
risk evaluation. However, methods for classification of variants resulting from this testing …