User profiles for Thomas Quail

Thomas Quail

EMBL, Cell Biology and Biophysics Unit
Verified email at embl.de
Cited by 522

Cohesin and condensin extrude DNA loops in a cell cycle-dependent manner

S Golfier, T Quail, H Kimura, J Brugués - Elife, 2020 - elifesciences.org
Loop extrusion by structural maintenance of chromosomes (SMC) complexes has been
proposed as a mechanism to organize chromatin in interphase and metaphase. However, the …

[HTML][HTML] Force generation by protein–DNA co-condensation

T Quail, S Golfier, M Elsner, K Ishihara, V Murugesan… - Nature Physics, 2021 - nature.com
Interactions between liquids and surfaces generate forces 1 , 2 that are crucial for many
processes in biology, physics and engineering, including the motion of insects on the surface of …

[PDF][PDF] PARP1-DNA co-condensation drives DNA repair site assembly to prevent disjunction of broken DNA ends

N Chappidi, T Quail, S Doll, LT Vogel, R Aleksandrov… - Cell, 2024 - cell.com
DNA double-strand breaks (DSBs) are repaired at DSB sites. How DSB sites assemble and
how broken DNA is prevented from separating is not understood. Here we uncover that the …

Vitamin D receptor as a master regulator of the c-MYC/MXD1 network

…, LE Tavera-Mendoza, T Quail… - Proceedings of the …, 2012 - National Acad Sciences
Vitamin D signaling regulates cell proliferation and differentiation, and epidemiological data
suggest that it functions as a cancer chemopreventive agent, although the underlying …

Predicting the onset of period-doubling bifurcations in noisy cardiac systems

T Quail, A Shrier, L Glass - Proceedings of the National …, 2015 - National Acad Sciences
Biological, physical, and social systems often display qualitative changes in dynamics.
Developing early warning signals to predict the onset of these transitions is an important goal. …

Spatial symmetry breaking determines spiral wave chirality

T Quail, A Shrier, L Glass - Physical review letters, 2014 - APS
Chirality represents a fundamental property of spiral waves. Introducing obstacles into cardiac
monolayers leads to the initiation of clockwise-rotating, counterclockwise-rotating, and …

Tunable oscillations and chaotic dynamics in systems with localized synthesis

F Naqib, T Quail, L Musa, H Vulpe, J Nadeau, J Lei… - Physical Review E, 2012 - APS
Biological systems contain biochemical control networks that reside within a remarkable
spatial structure. We present a theoretical study of a biological system in which two chemically …

Computational study of synchrony in fields and microclusters of ephaptically coupled neurons

RG Stacey, L Hilbert, T Quail - Journal of neurophysiology, 2015 - journals.physiology.org
Neuronal hypersynchrony is implicated in epilepsy and other diseases. The low-frequency,
spatially averaged electric fields from many thousands of neurons have been shown to …

Capillary forces drive pioneer transcription factor-mediated DNA condensation

T Quail, S Golfier, M Elsner, K Ishihara, F Jülicher… - BioRxiv, 2020 - biorxiv.org
Capillary forces are driven by interactions between liquids and surfaces 1 . These forces are
crucial for many processes ranging from biology and physics to engineering, such as the …

SPECIAL REPORT: Overview of Silica-Related Clusters in the United States: Will Fracking Operations Become the Next Cluster?

MT Quail - Journal of Environmental Health, 2017 - JSTOR
Silicosis is the oldest know occupational pulmonary disease. It is a progressive disease and
any level of exposure to respirable crystalline silica particles or dust has the potential to …