A nonlinear model predictive controller has been developed to maintain normoglycemia in
subjects with type 1 diabetes during fasting conditions such as during overnight fast. The …

Vitamin D metabolizing enzymes and vitamin D receptors are present in many cell types
including various immune cells such as antigen-presenting-cells, T cells, B cells and monocytes…

Background Degludec is an ultralong-acting, once-daily basal insulin that is approved for
use in adults, adolescents, and children with diabetes. Previous open-label studies have …

Pharmacologically induced glycosuria elicits adaptive responses in glucose homeostasis and
hormone release. In type 2 diabetes (T2D), along with decrements in plasma glucose and …

Background Despite indications from epidemiological trials that higher blood glucose
concentrations are associated with a higher risk for developing micro‐and macrovascular …

Vitamin D deficiency is common and is primarily caused by a lack of ultraviolet-B (UVB)
radiation from reduced sun exposure, and the consequent limiting of vitamin D production in the …

Background The feasibility, safety, and efficacy of prolonged use of an artificial beta cell (closed-loop
insulin-delivery system) in the home setting have not been established. Methods In …

Importance Low vitamin D status is linked to increased mortality and morbidity in patients who
are critically ill. It is unknown if this association is causal. Objective To investigate whether …

A poor vitamin D status, ie low serum levels of 25‐hydroxyvitamin D [25(OH)D], is common
in the general population. This finding is of concern not only because of the classic vitamin D …

Background In short acting insulin analogues the dissociation of hexamers is facilitated,
achieving peak plasma concentrations about twice as high and within approximately half the …