Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has undergone progressive
change, with variants conferring advantage rapidly becoming dominant lineages, eg, B.…

The race to produce vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
began when the first sequence was published, and this forms the basis for …

Terminating the SARS-CoV-2 pandemic relies upon pan-global vaccination. Current
vaccines elicit neutralizing antibody responses to the virus spike derived from early isolates. …

SARS-CoV-2 has caused over 2 million deaths in little over a year. Vaccines are being
deployed at scale, aiming to generate responses against the virus spike. The scale of the …

Enterovirus 71 (EV71) is a major agent of hand, foot and mouth disease in children that can
cause severe central nervous system disease and death. No vaccine or antiviral therapy is …

Antibodies are crucial to immune protection against SARS-CoV-2, with some in emergency
use as therapeutics. Here, we identify 377 human monoclonal antibodies (mAbs) …

Crystallization remains a critical step in X-ray structure determination. Because it is not
generally possible to rationally predict crystallization conditions, commercial screens have been …

A crystallization screening process is presented that was developed for a small academic
laboratory. Its underlying concept is to combine sparse-matrix screening with systematic …

Crystallization trials at the Division of Structural Biology in Oxford are now almost exclusively
carried out using a high-throughput workflow implemented in the Oxford Protein Production …

Bone remodeling involves bone resorption by osteoclasts and synthesis by osteoblasts and
is tightly regulated by the receptor activator of the NF-κB ligand (RANKL)/receptor activator …