User profiles for Thomas Simonet
Thomas M. SimonetEcole Polytechnique Fédérale de Lausanne (EPFL) Verified email at epfl.ch Cited by 60 |
[PDF][PDF] De novo mutations in protein kinase genes CAMK2A and CAMK2B cause intellectual disability
…, E Charpentier, CB Nowak, E Cherot, T Simonet… - The American Journal of …, 2017 - cell.com
Calcium/calmodulin-dependent protein kinase II (CAMK2) is one of the first proteins shown
to be essential for normal learning and synaptic plasticity in mice, but its requirement for …
to be essential for normal learning and synaptic plasticity in mice, but its requirement for …
[HTML][HTML] The human TTAGGG repeat factors 1 and 2 bind to a subset of interstitial telomeric sequences and satellite repeats
T Simonet, LE Zaragosi, C Philippe, K Lebrigand… - Cell research, 2011 - nature.com
The study of the proteins that bind to telomeric DNA in mammals has provided a deep
understanding of the mechanisms involved in chromosome-end protection. However, very little is …
understanding of the mechanisms involved in chromosome-end protection. However, very little is …
Muscle histone deacetylase 4 upregulation in amyotrophic lateral sclerosis: potential role in reinnervation ability and disease progression
G Bruneteau, T Simonet, S Bauché, N Mandjee… - Brain, 2013 - academic.oup.com
Amyotrophic lateral sclerosis is a typically rapidly progressive neurodegenerative disorder
affecting motor neurons leading to progressive muscle paralysis and death, usually from …
affecting motor neurons leading to progressive muscle paralysis and death, usually from …
TRF2 inhibits a cell-extrinsic pathway through which natural killer cells eliminate cancer cells
…, A Augereau, S Pinte, S Bauwens, J Ye, T Simonet… - Nature cell …, 2013 - nature.com
Dysfunctional telomeres suppress tumour progression by activating cell-intrinsic programs
that lead to growth arrest. Increased levels of TRF2, a key factor in telomere protection, are …
that lead to growth arrest. Increased levels of TRF2, a key factor in telomere protection, are …
Dynamic persistence of UPEC intracellular bacterial communities in a human bladder-chip model of urinary tract infection
Uropathogenic Escherichia coli (UPEC) proliferate within superficial bladder umbrella cells
to form intracellular bacterial communities (IBCs) during early stages of urinary tract infections…
to form intracellular bacterial communities (IBCs) during early stages of urinary tract infections…
Caenorhabditis elegans chromatin-associated proteins SET-2 and ASH-2 are differentially required for histone H3 Lys 4 methylation in embryos and adult germ cells
…, C Bedet, VJP Robert, T Simonet… - Proceedings of the …, 2011 - National Acad Sciences
Methylation of histone H3 lysine 4 (H3K4me), a mark associated with gene activation, is
mediated by SET1 and the related mixed lineage leukemia (MLL) histone methyltransferases (…
mediated by SET1 and the related mixed lineage leukemia (MLL) histone methyltransferases (…
Telomere protection and TRF2 expression are enhanced by the canonical Wnt signalling pathway
…, S Bauwens, C Schluth‐Bolard, T Simonet… - EMBO …, 2013 - embopress.org
The DNA‐binding protein TRF2 is essential for telomere protection and chromosome
stability in mammals. We show here that TRF2 expression is activated by the Wnt/β‐catenin …
stability in mammals. We show here that TRF2 expression is activated by the Wnt/β‐catenin …
Homozygous COQ7 mutation: a new cause of potentially treatable distal hereditary motor neuropathy
…, S Ribault, V Risson, J Carras, L Coudert, T Simonet… - Brain, 2023 - academic.oup.com
Distal hereditary motor neuropathy represents a group of motor inherited neuropathies
leading to distal weakness. We report a family of two brothers and a sister affected by distal …
leading to distal weakness. We report a family of two brothers and a sister affected by distal …
Contribution of rare and predicted pathogenic gene variants to childhood-onset lupus: a large, genetic panel analysis of British and French cohorts
…, P Abou-Jaoude, IN Bruce, T Simonet… - The Lancet …, 2020 - thelancet.com
Background Systemic lupus erythematosus (SLE) is a rare immunological disorder and genetic
factors are considered important in its causation. Monogenic lupus has been associated …
factors are considered important in its causation. Monogenic lupus has been associated …
[PDF][PDF] LSD1 controls timely MyoD expression via MyoD core enhancer transcription
…, E Girard, JE de Lima, V Morel, T Simonet… - Cell reports, 2017 - cell.com
MyoD is a master regulator of myogenesis. Chromatin modifications required to trigger MyoD
expression are still poorly described. Here, we demonstrate that the histone demethylase …
expression are still poorly described. Here, we demonstrate that the histone demethylase …