The chimeric anti-CD20 MAb rituximab has recently become a treatment of choice for low-grade
or follicular non-Hodgkin's lymphomas (FL) with a response rate of about 50%. In this …

Cell-cell signaling coordinates proliferation of metazoan tissues during development, and
its alteration can induce malignant transformation. Endocytosis regulates signaling by …

Eukaryotes use autophagy to turn over organelles, protein aggregates, and cytoplasmic
constituents. The impairment of autophagy causes developmental defects, starvation sensitivity, …

Macroautophagy/autophagy, a defense mechanism against aberrant stresses, in neurons
counteracts aggregate-prone misfolded protein toxicity. Autophagy induction might be …

Signaling through the transmembrane receptor Notch is widely used throughout animal
development and is a major regulator of cell proliferation and differentiation. During canonical …

Evidence indicates that endosomal entry promotes signaling by the Notch receptor, but the
mechanisms involved are not clear. In a search for factors that regulate Notch activation in …

ESCRT proteins were initially isolated in yeast as a single functional set of conserved
components controlling endosomal cargo sorting and multivesicular body (MVB) biogenesis. …

A prevailing paradigm posits that Polycomb Group (PcG) proteins maintain stem cell identity
by repressing differentiation genes, and abundant evidence points to an oncogenic role for …

Originally identified for their involvement in endosomal sorting and multivesicular endosome
(MVE) biogenesis, components of the endosomal sorting complex required for transport (…

Intestinal barrier dysfunction leads to inflammation and associated metabolic changes.
However, the relative impact of gut bacteria versus non-bacterial insults on animal health in the …