Objectives: Myeloid-derived suppressor cells (MDSCs) have been described as suppressors
of T-cell functions in many tumor models. However, MDSC in HIV-1 infection have not been …

The vertebrate adaptive immune system modifies the genome of individual B cells to encode
antibodies that bind particular antigens 1 . In most mammals, antibodies are composed of …

HIV broadly neutralizing antibodies (bnAbs) can suppress viremia and protect against HIV
infection. However, their elicitation is made difficult by low frequencies of appropriate …

The VH1-2 restricted VRC01-class of antibodies targeting the HIV envelope CD4 binding
site are a major focus of HIV vaccine strategies. However, a detailed analysis of VRC01-class …

The membrane-proximal external region (MPER) of HIV-1 envelope glycoprotein (Env) can
be targeted by neutralizing antibodies of exceptional breadth. MPER antibodies usually have …

Molecular evolutionary arms races between viruses and their hosts are important drivers of
adaptation. These Red Queen dynamics have been frequently observed in primate …

HIV reservoirs persist in anatomic compartments despite antiretroviral therapy (ART).
Characterizing archival HIV DNA in the central nervous system (CNS) and other tissues is crucial to …

The plasma membrane is a site of conflict between host defenses and many viruses. One
aspect of this conflict is the host’s attempt to eliminate infected cells using innate and adaptive …

Vaccination strategies aimed at maturing broadly neutralizing antibodies (bnAbs) from
naïve precursors are hindered by unusual features that characterize these Abs, including …

Purpose To evaluate the diagnostic performance of layer-specific cardiac MRI feature-tracking
(FT) strain analysis in patients with acute myocarditis. Materials and Methods Seventy …