Sensitive periods for the effect of childhood adversity on DNA methylation: results from a prospective, longitudinal study
Background Exposure to early-life adversity is known to predict DNA methylation (DNAm)
patterns that may be related to psychiatric risk. However, few studies have investigated …
patterns that may be related to psychiatric risk. However, few studies have investigated …
What life course theoretical models best explain the relationship between exposure to childhood adversity and psychopathology symptoms: recency, accumulation, or …
BackgroundAlthough childhood adversity is a potent determinant of psychopathology,
relatively little is known about how the characteristics of adversity exposure, including its …
relatively little is known about how the characteristics of adversity exposure, including its …
Adversity exposure during sensitive periods predicts accelerated epigenetic aging in children
Objectives Exposure to adversity has been linked to accelerated biological aging, which in
turn has been shown to predict numerous physical and mental health problems. In recent …
turn has been shown to predict numerous physical and mental health problems. In recent …
Genome‐wide association study (GWAS) and genome‐wide by environment interaction study (GWEIS) of depressive symptoms in African American and Hispanic …
Background Genome‐wide association studies (GWAS) have made little progress in identifying
variants linked to depression. We hypothesized that examining depressive symptoms …
variants linked to depression. We hypothesized that examining depressive symptoms …
Transplanted organoids empower human preclinical assessment of drug candidate for the clinic
AD Westerling-Bui, EM Fast, TW Soare… - Science …, 2022 - science.org
Pharmacodynamic (PD) studies are an essential component of preclinical drug discovery.
Current approaches for PD studies, including the analysis of novel kidney disease targeting …
Current approaches for PD studies, including the analysis of novel kidney disease targeting …
Exposure to early childhood maltreatment and its effect over time on social cognition
Social cognitive deficits can have many negative consequences, spanning social withdrawal
to psychopathology. Prior work has shown that child maltreatment may associate with …
to psychopathology. Prior work has shown that child maltreatment may associate with …
Exposure to childhood adversity and deficits in emotion recognition: results from a large, population‐based sample
EC Dunn, KM Crawford, TW Soare… - Journal of Child …, 2018 - Wiley Online Library
Background Emotion recognition skills are essential for social communication. Deficits in
these skills have been implicated in mental disorders. Prior studies of clinical and high‐risk …
these skills have been implicated in mental disorders. Prior studies of clinical and high‐risk …
Association of prenatal exposure to population-wide folic acid fortification with altered cerebral cortex maturation in youths
…, A Rodriguez-Thompson, TW Soare… - JAMA …, 2018 - jamanetwork.com
Importance Presently, 81 countries mandate the fortification of grain products with folic acid
to lessen the risk of neural tube defects in the developing fetus. Epidemiologic data on …
to lessen the risk of neural tube defects in the developing fetus. Epidemiologic data on …
[PDF][PDF] An allelic-series rare-variant association test for candidate-gene discovery
Allelic series are of candidate therapeutic interest because of the existence of a dose-response
relationship between the functionality of a gene and the degree or severity of a …
relationship between the functionality of a gene and the degree or severity of a …
Genetic evidence for landscape effects on dispersal in the army ant Eciton burchellii
Inhibited dispersal, leading to reduced gene flow, threatens populations with inbreeding
depression and local extinction. Fragmentation may be especially detrimental to social insects …
depression and local extinction. Fragmentation may be especially detrimental to social insects …