Sensitive periods for the effect of childhood adversity on DNA methylation: results from a prospective, longitudinal study

EC Dunn, TW Soare, Y Zhu, AJ Simpkin… - Biological …, 2019 - Elsevier
Background Exposure to early-life adversity is known to predict DNA methylation (DNAm)
patterns that may be related to psychiatric risk. However, few studies have investigated …

What life course theoretical models best explain the relationship between exposure to childhood adversity and psychopathology symptoms: recency, accumulation, or …

EC Dunn, TW Soare, MR Raffeld, DS Busso… - Psychological …, 2018 - cambridge.org
BackgroundAlthough childhood adversity is a potent determinant of psychopathology,
relatively little is known about how the characteristics of adversity exposure, including its …

Adversity exposure during sensitive periods predicts accelerated epigenetic aging in children

S Marini, KA Davis, TW Soare, Y Zhu… - …, 2020 - Elsevier
Objectives Exposure to adversity has been linked to accelerated biological aging, which in
turn has been shown to predict numerous physical and mental health problems. In recent …

Genome‐wide association study (GWAS) and genome‐wide by environment interaction study (GWEIS) of depressive symptoms in African American and Hispanic …

…, JA Smith, DR Weir, W Zhao, TW Soare… - Depression and …, 2016 - Wiley Online Library
Background Genome‐wide association studies (GWAS) have made little progress in identifying
variants linked to depression. We hypothesized that examining depressive symptoms …

Transplanted organoids empower human preclinical assessment of drug candidate for the clinic

AD Westerling-Bui, EM Fast, TW Soare… - Science …, 2022 - science.org
Pharmacodynamic (PD) studies are an essential component of preclinical drug discovery.
Current approaches for PD studies, including the analysis of novel kidney disease targeting …

Exposure to early childhood maltreatment and its effect over time on social cognition

…, K Choi, KA Davis, Y Zhu, TW Soare… - Development and …, 2022 - cambridge.org
Social cognitive deficits can have many negative consequences, spanning social withdrawal
to psychopathology. Prior work has shown that child maltreatment may associate with …

Exposure to childhood adversity and deficits in emotion recognition: results from a large, population‐based sample

EC Dunn, KM Crawford, TW Soare… - Journal of Child …, 2018 - Wiley Online Library
Background Emotion recognition skills are essential for social communication. Deficits in
these skills have been implicated in mental disorders. Prior studies of clinical and high‐risk …

Association of prenatal exposure to population-wide folic acid fortification with altered cerebral cortex maturation in youths

…, A Rodriguez-Thompson, TW Soare… - JAMA …, 2018 - jamanetwork.com
Importance Presently, 81 countries mandate the fortification of grain products with folic acid
to lessen the risk of neural tube defects in the developing fetus. Epidemiologic data on …

[PDF][PDF] An allelic-series rare-variant association test for candidate-gene discovery

…, T Karaletsos, FP Casale, D Koller, TW Soare - The American Journal of …, 2023 - cell.com
Allelic series are of candidate therapeutic interest because of the existence of a dose-response
relationship between the functionality of a gene and the degree or severity of a …

Genetic evidence for landscape effects on dispersal in the army ant Eciton burchellii

TW Soare, A Kumar, KA Naish… - Molecular ecology, 2014 - Wiley Online Library
Inhibited dispersal, leading to reduced gene flow, threatens populations with inbreeding
depression and local extinction. Fragmentation may be especially detrimental to social insects …