User profiles for Thomas Walle
Thomas WalleGerman Cancer Research Center Verified email at dkfz.de Cited by 903 |
High absorption but very low bioavailability of oral resveratrol in humans
T Walle, F Hsieh, MH DeLegge, JE Oatis… - Drug metabolism and …, 2004 - ASPET
The dietary polyphenol resveratrol has been shown to have chemopreventive activity
against cardiovascular disease and a variety of cancers in model systems, but it is not clear …
against cardiovascular disease and a variety of cancers in model systems, but it is not clear …
[HTML][HTML] Flavonoid glucosides are hydrolyzed and thus activated in the oral cavity in humans
T Walle, AM Browning, LL Steed, SG Reed… - The Journal of nutrition, 2005 - Elsevier
Increasing epidemiological evidence supports the view that dietary flavonoids have protective
roles in oral diseases, including cancer. However, the dietary forms of flavonoids, the …
roles in oral diseases, including cancer. However, the dietary forms of flavonoids, the …
Bioavailability of resveratrol
T Walle - Annals of the new York Academy of Sciences, 2011 - Wiley Online Library
This paper reviews our current understanding of the absorption, bioavailability, and
metabolism of resveratrol, with an emphasis on humans. The oral absorption of resveratrol in …
metabolism of resveratrol, with an emphasis on humans. The oral absorption of resveratrol in …
Absorption and metabolism of flavonoids
T Walle - Free radical biology and medicine, 2004 - Elsevier
The benefits of flavonoids as chemopreventive dietary or dietary supplemental agents are
still only “potential.” Much has been learned about possible mechanisms of action of these …
still only “potential.” Much has been learned about possible mechanisms of action of these …
[HTML][HTML] What is new for an old molecule? Systematic review and recommendations on the use of resveratrol
…, Y Shukla, YJ Surh, T Szekeres, T Szkudelski, T Walle… - PloS one, 2011 - journals.plos.org
Background Resveratrol is a natural compound suggested to have beneficial health effects.
However, people are consuming resveratrol for this reason without having the adequate …
However, people are consuming resveratrol for this reason without having the adequate …
[PDF][PDF] Signatures of plasticity, metastasis, and immunosuppression in an atlas of human small cell lung cancer
Small cell lung cancer (SCLC) is an aggressive malignancy that includes subtypes defined
by differential expression of ASCL1, NEUROD1, and POU2F3 (SCLC-A, -N, and -P, …
by differential expression of ASCL1, NEUROD1, and POU2F3 (SCLC-A, -N, and -P, …
Methylated flavonoids have greatly improved intestinal absorption and metabolic stability
X Wen, T Walle - Drug metabolism and disposition, 2006 - ASPET
To better understand the relationship between the chemical structure and biological fate of
dietary polyphenols, the hepatic metabolic stability and intestinal absorption of methylated …
dietary polyphenols, the hepatic metabolic stability and intestinal absorption of methylated …
Cellular uptake of dietary flavonoid quercetin 4′-β-glucoside by sodium-dependent glucose transporter SGLT1
RA Walgren, JT Lin, RKH Kinne, T Walle - Journal of Pharmacology and …, 2000 - ASPET
Although it has been suggested that the intestinal glucose transporter may actively absorb
dietary flavonoid glucosides, there is a lack of direct evidence for their transport by this system…
dietary flavonoid glucosides, there is a lack of direct evidence for their transport by this system…
Methoxylated flavones, a superior cancer chemopreventive flavonoid subclass?
T Walle - Seminars in cancer biology, 2007 - Elsevier
Dietary flavonoids and other polyphenols show great potential as cancer chemopreventive
agents in cell culture studies. This does not translate well into in vivo activity, because of …
agents in cell culture studies. This does not translate well into in vivo activity, because of …
Cellular uptake and efflux of the tea flavonoid (-) epicatechin-3-gallate in the human intestinal cell line Caco-2
JB Vaidyanathan, T Walle - Journal of Pharmacology and Experimental …, 2003 - ASPET
(-)-Epicatechin gallate (ECG) is one of the flavonoids in green tea, which has been demonstrated
to have cancer-preventive properties in many model systems. However, the extent and …
to have cancer-preventive properties in many model systems. However, the extent and …