User profiles for Thomas Walle

Thomas Walle

German Cancer Research Center
Verified email at dkfz.de
Cited by 903

High absorption but very low bioavailability of oral resveratrol in humans

T Walle, F Hsieh, MH DeLegge, JE Oatis… - Drug metabolism and …, 2004 - ASPET
The dietary polyphenol resveratrol has been shown to have chemopreventive activity
against cardiovascular disease and a variety of cancers in model systems, but it is not clear …

[HTML][HTML] Flavonoid glucosides are hydrolyzed and thus activated in the oral cavity in humans

T Walle, AM Browning, LL Steed, SG Reed… - The Journal of nutrition, 2005 - Elsevier
Increasing epidemiological evidence supports the view that dietary flavonoids have protective
roles in oral diseases, including cancer. However, the dietary forms of flavonoids, the …

Bioavailability of resveratrol

T Walle - Annals of the new York Academy of Sciences, 2011 - Wiley Online Library
This paper reviews our current understanding of the absorption, bioavailability, and
metabolism of resveratrol, with an emphasis on humans. The oral absorption of resveratrol in …

Absorption and metabolism of flavonoids

T Walle - Free radical biology and medicine, 2004 - Elsevier
The benefits of flavonoids as chemopreventive dietary or dietary supplemental agents are
still only “potential.” Much has been learned about possible mechanisms of action of these …

[HTML][HTML] What is new for an old molecule? Systematic review and recommendations on the use of resveratrol

…, Y Shukla, YJ Surh, T Szekeres, T Szkudelski, T Walle… - PloS one, 2011 - journals.plos.org
Background Resveratrol is a natural compound suggested to have beneficial health effects.
However, people are consuming resveratrol for this reason without having the adequate …

[PDF][PDF] Signatures of plasticity, metastasis, and immunosuppression in an atlas of human small cell lung cancer

…, O Chaudhary, I Masilionis, J Egger, A Chow, T Walle… - Cancer cell, 2021 - cell.com
Small cell lung cancer (SCLC) is an aggressive malignancy that includes subtypes defined
by differential expression of ASCL1, NEUROD1, and POU2F3 (SCLC-A, -N, and -P, …

Methylated flavonoids have greatly improved intestinal absorption and metabolic stability

X Wen, T Walle - Drug metabolism and disposition, 2006 - ASPET
To better understand the relationship between the chemical structure and biological fate of
dietary polyphenols, the hepatic metabolic stability and intestinal absorption of methylated …

Cellular uptake of dietary flavonoid quercetin 4′-β-glucoside by sodium-dependent glucose transporter SGLT1

RA Walgren, JT Lin, RKH Kinne, T Walle - Journal of Pharmacology and …, 2000 - ASPET
Although it has been suggested that the intestinal glucose transporter may actively absorb
dietary flavonoid glucosides, there is a lack of direct evidence for their transport by this system…

Methoxylated flavones, a superior cancer chemopreventive flavonoid subclass?

T Walle - Seminars in cancer biology, 2007 - Elsevier
Dietary flavonoids and other polyphenols show great potential as cancer chemopreventive
agents in cell culture studies. This does not translate well into in vivo activity, because of …

Cellular uptake and efflux of the tea flavonoid (-) epicatechin-3-gallate in the human intestinal cell line Caco-2

JB Vaidyanathan, T Walle - Journal of Pharmacology and Experimental …, 2003 - ASPET
(-)-Epicatechin gallate (ECG) is one of the flavonoids in green tea, which has been demonstrated
to have cancer-preventive properties in many model systems. However, the extent and …