The determinant of verapamil-reversible chloroquine resistance (CQR) in a Plasmodium
falciparum genetic cross maps to a 36 kb segment of chromosome 7. This segment harbors a 13…

The human malaria parasite Plasmodium faiciparum evades host immunity by varying the
antigenic and adhesive character of infected erythrocytes. We describe a large and extremely …

Background Chloroquine-resistant Plasmodium falciparum malaria is a major health problem,
particularly in sub-Saharan Africa. Chloroquine resistance has been associated in vitro …

The development of chloroquine as an antimalarial drug and the subsequent evolution of
drug-resistant Plasmodium strains had major impacts on global public health in the 20th …

Malaria parasites are haploid for most of their life cycle, with zygote formation and meiosis
occurring during the mosquito phase of development. The parasites can be analyzed …

Analysis of a genetic cross of Plasmodium falciparum and of independent parasite isolates
from Southeast Asia, Africa, and South America indicates that resistance to pyrimethamine, …

As chloroquine resistance spreads across Africa, the dihydrofolate reductase (DHFR)
inhibitors pyrimethamine and proguanil are being used as alternative first-line drugs for the …

Plasmodium falciparum malaria, an infectious disease caused by a parasitic protozoan,
claims the lives of nearly a million children each year in Africa alone and is a top public health …

CHLOROQUINE is thought to act against falciparum malaria by accumulating in the acid
vesicles of the parasite and interfering with their function 1–4 . Parasites resistant to chloroquine …

Persistent and recurrent infections by Plasmodium falciparum malaria parasites result from
the ability of the parasite to undergo antigenic variation and evade host immune attack 1 , 2 . …