Primary triple-negative breast cancers (TNBCs), a tumour type defined by lack of oestrogen
receptor, progesterone receptor and ERBB2 gene amplification, represent approximately 16…

Follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL) are the two most
common non-Hodgkin lymphomas (NHLs). Here we sequenced tumour and matched normal …

Background Ovarian clear-cell and endometrioid carcinomas may arise from endometriosis,
but the molecular events involved in this transformation have not been described. Methods …

We developed a method, ChIP-sequencing (ChIP-seq), combining chromatin immunoprecipitation
(ChIP) and massively parallel sequencing to identify mammalian DNA sequences …

MicroRNAs (miRNAs) are emerging as important, albeit poorly characterized, regulators of
biological processes. Key to further elucidation of their roles is the generation of more …

Background Granulosa-cell tumors (GCTs) are the most common type of malignant ovarian
sex cord–stromal tumor (SCST). The pathogenesis of these tumors is unknown. Moreover, …

High‐grade serous ovarian cancer ( HGSC ) is characterized by poor outcome, often attributed
to the emergence of treatment‐resistant subclones. We sought to measure the degree of …

We describe a new method, Tag-seq, which employs ultra high-throughput sequencing of
21 base pair cDNA tags for sensitive and cost-effective gene expression profiling. We …

Massively parallel sequencing is a useful approach for characterizing T-cell receptor diversity.
However, immune receptors are extraordinarily difficult sequencing targets because any …

In alternative expression analysis by sequencing (ALEXA-seq), we developed a method to
analyze massively parallel RNA sequence data to catalog transcripts and assess differential …