User profiles for Thuy T. M. Ngo
 | Thuy NgoAssistant Professor, Oregon Health and Science University Verified email at ohsu.edu Cited by 1910 |
[PDF][PDF] Asymmetric unwrapping of nucleosomes under tension directed by DNA local flexibility
Dynamics of the nucleosome and exposure of nucleosomal DNA play key roles in many
nuclear processes, but local dynamics of the nucleosome and its modulation by DNA sequence …
nuclear processes, but local dynamics of the nucleosome and its modulation by DNA sequence …
Noninvasive blood tests for fetal development predict gestational age and preterm delivery
TTM Ngo, MN Moufarrej, MLH Rasmussen… - Science, 2018 - science.org
Noninvasive blood tests that provide information about fetal development and gestational
age could potentially improve prenatal care. Ultrasound, the current gold standard, is not …
age could potentially improve prenatal care. Ultrasound, the current gold standard, is not …
[HTML][HTML] Effects of cytosine modifications on DNA flexibility and nucleosome mechanical stability
Cytosine can undergo modifications, forming 5-methylcytosine (5-mC) and its oxidized
products 5-hydroxymethylcytosine (5-hmC), 5-formylcytosine (5-fC) and 5-carboxylcytosine (5-caC…
products 5-hydroxymethylcytosine (5-hmC), 5-formylcytosine (5-fC) and 5-carboxylcytosine (5-caC…
Multiomics modeling of the immunome, transcriptome, microbiome, proteome and metabolome adaptations during human pregnancy
Motivation Multiple biological clocks govern a healthy pregnancy. These biological mechanisms
produce immunologic, metabolomic, proteomic, genomic and microbiomic adaptations …
produce immunologic, metabolomic, proteomic, genomic and microbiomic adaptations …
Measuring DNA mechanics on the genome scale
Mechanical deformations of DNA such as bending are ubiquitous and have been implicated
in diverse cellular functions 1 . However, the lack of high-throughput tools to measure the …
in diverse cellular functions 1 . However, the lack of high-throughput tools to measure the …
Defining single molecular forces required for notch activation using nano yoyo
Notch signaling, involved in development and tissue homeostasis, is activated at the cell–cell
interface through ligand–receptor interactions. Previous studies have implicated …
interface through ligand–receptor interactions. Previous studies have implicated …
A coarse-grained model of unstructured single-stranded DNA derived from atomistic simulation and single-molecule experiment
A simple coarse-grained model of single-stranded DNA (ssDNA) was developed, featuring
only two sites per nucleotide that represent the centers of mass of the backbone and sugar/…
only two sites per nucleotide that represent the centers of mass of the backbone and sugar/…
[HTML][HTML] Plasma cell-free RNA profiling distinguishes cancers from pre-malignant conditions in solid and hematologic malignancies
…, K Farsad, WE Naugler, TTM Ngo - NPJ Precision …, 2022 - nature.com
Cell-free RNA (cfRNA) in plasma reflects phenotypic alterations of both localized sites of
cancer and the systemic host response. Here we report that cfRNA sequencing enables the …
cancer and the systemic host response. Here we report that cfRNA sequencing enables the …
Simultaneously monitoring immune response and microbial infections during pregnancy through plasma cfRNA sequencing
BACKGROUND Plasma cell-free RNA (cfRNA) encompasses a broad spectrum of RNA species
that can be derived from both human cells and microbes. Because cfRNA is fragmented …
that can be derived from both human cells and microbes. Because cfRNA is fragmented …
Nucleosomes undergo slow spontaneous gaping
In eukaryotes, DNA is packaged into a basic unit, the nucleosome which consists of 147 bp
of DNA wrapped around a histone octamer composed of two copies each of the histones H2A…
of DNA wrapped around a histone octamer composed of two copies each of the histones H2A…