User profiles for Tia A. Tummino

Tia Tummino

University of California San Francisco
Verified email at ucsf.edu
Cited by 5439

[HTML][HTML] A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

…, VV Rezelj, JZ Guo, DL Swaney, TA Tummino… - Nature, 2020 - nature.com
A newly described coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
which is the causative agent of coronavirus disease 2019 (COVID-19), has …

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms

…, Z Cakir, G Jang, MJ O'meara, TA Tummino… - Science, 2020 - science.org
INTRODUCTION The emergence of three lethal coronaviruses in <20 years and the urgency
of the COVID-19 pandemic have prompted efforts to develop new therapeutic strategies, …

Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2

TA Tummino, VV Rezelj, B Fischer, A Fischer… - Science, 2021 - science.org
Repurposing drugs as treatments for COVID-19, the disease caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has drawn much attention. Beginning with …

Structures of the σ2 receptor enable docking for bioactive ligand discovery

A Alon, J Lyu, JM Braz, TA Tummino, V Craik… - Nature, 2021 - nature.com
The σ 2 receptor has attracted intense interest in cancer imaging 1 , psychiatric disease 2 ,
neuropathic pain 3 , 4 – 5 and other areas of biology 6 , 7 . Here we determined the crystal …

[HTML][HTML] Proteomic and genetic analyses of influenza A viruses identify pan-viral host targets

…, Y Zhou, G Metreveli, B Harjai, TA Tummino… - Nature …, 2023 - nature.com
Influenza A Virus (IAV) is a recurring respiratory virus with limited availability of antiviral
therapies. Understanding host proteins essential for IAV infection can identify targets for …

[PDF][PDF] A SARS-CoV-2-human protein-protein interaction map reveals drug targets and potential drug-repurposing

MJ O'Meara, JZ Guo, DL Swaney, TA Tummino… - BioRxiv, 2020 - biorxiv.org
An outbreak of the novel coronavirus SARS-CoV-2, the causative agent of COVID-19
respiratory disease, has infected over 290,000 people since the end of 2019, killed over 12,000, …

Registered replication report on fischer, castel, dodd, and pratt (2003)

…, MS Saviano, TA Tummino… - … in Methods and …, 2020 - journals.sagepub.com
The attentional spatial-numerical association of response codes (Att-SNARC) effect (Fischer,
Castel, Dodd, & Pratt, 2003)—the finding that participants are quicker to detect left-side …

Colloidal aggregators in biochemical SARS-CoV-2 repurposing screens

HR O'Donnell, TA Tummino, C Bardine… - Journal of medicinal …, 2021 - ACS Publications
To fight COVID-19, much effort has been directed toward in vitro drug repurposing. Here, we
investigate the impact of colloidal aggregation, a common screening artifact, in these …

Comparative morphology of gigantopyramidal neurons in primary motor cortex across mammals

…, M Schall, MS Saviano, TA Tummino… - Journal of …, 2018 - Wiley Online Library
Gigantopyramidal neurons, referred to as Betz cells in primates, are characterized by large
somata and extensive basilar dendrites. Although there have been morphological …

[HTML][HTML] Phospholipidosis is a shared mechanism underlying the in vitro antiviral activity of many repurposed drugs against SARS-CoV-2

TA Tummino, VV Rezelj, B Fischer, A Fischer… - bioRxiv, 2021 - ncbi.nlm.nih.gov
Repurposing drugs as treatments for COVID-19 has drawn much attention. A common strategy
has been to screen for established drugs, typically developed for other indications, that …