Escaping from imminent danger is an instinctive behaviour that is fundamental for survival,
and requires the classification of sensory stimuli as harmless or threatening. The absence of …

When faced with potential predators, animals instinctively decide whether there is a threat
they should escape from, and also when, how, and where to take evasive action. While …

The conventional view of dendritic function is that dendrites collect synaptic input and deliver
it to the soma. This view has been challenged in recent years by new results demonstrating …

Abstract Information transfer at chemical synapses occurs when vesicles fuse with the plasma
membrane and release neurotransmitter. This process is stochastic and its likelihood of …

Escape is one of the most studied animal behaviors, and there is a rich normative theory
that links threat properties to evasive actions and their timing. The behavioral principles of …

The detection and discrimination of temporal sequences is fundamental to brain function
and underlies perception, cognition, and motor output. By applying patterned, two-photon …

Animals can choose to act upon, or to ignore, sensory stimuli, depending on circumstance
and prior knowledge. This flexibility is thought to depend on neural inhibition, through …

10.7554/eLife.09800.001 Molecular and cellular processes in neurons are critical for sensing
and responding to energy deficit states, such as during weight-loss. Agouti related protein (…

The prefrontal cortex helps adjust an organism's behavior to its environment. In particular,
numerous studies have implicated the prefrontal cortex in the control of social behavior, but …

Neuronal dendrites are electrically excitable: they can generate regenerative events such
as dendritic spikes in response to sufficiently strong synaptic input 1 , 2 , 3 . Although such …