Autism-like behaviours and germline transmission in transgenic monkeys overexpressing MeCP2
Z Liu, X Li, JT Zhang, YJ Cai, TL Cheng, C Cheng… - Nature, 2016 - nature.com
Methyl-CpG binding protein 2 (MeCP2) has crucial roles in transcriptional regulation and
microRNA processing 1 , 2 , 3 , 4 . Mutations in the MECP2 gene are found in 90% of patients …
microRNA processing 1 , 2 , 3 , 4 . Mutations in the MECP2 gene are found in 90% of patients …
[PDF][PDF] MeCP2 suppresses nuclear microRNA processing and dendritic growth by regulating the DGCR8/Drosha complex
Loss- and gain-of-function mutations of the X-linked gene MECP2 (methyl-CpG binding
protein 2) lead to severe neurodevelopmental disorders in humans, such as Rett syndrome (RTT…
protein 2) lead to severe neurodevelopmental disorders in humans, such as Rett syndrome (RTT…
[HTML][HTML] Conditional deletion of Mecp2 in parvalbumin-expressing GABAergic cells results in the absence of critical period plasticity
Mutations in the X-linked gene encoding the transcriptional modulator methyl–CpG-binding
protein 2 (MeCP2) impair postnatal development of the brain. Here we use neuronal-type …
protein 2 (MeCP2) impair postnatal development of the brain. Here we use neuronal-type …
Enhancement of superconductivity by pressure-driven competition in electronic order
Finding ways to achieve higher values of the transition temperature, T c , in superconductors
remains a great challenge. The superconducting phase is often one of several competing …
remains a great challenge. The superconducting phase is often one of several competing …
[HTML][HTML] Expanding C–T base editing toolkit with diversified cytidine deaminases
TL Cheng, S Li, B Yuan, X Wang, W Zhou… - Nature …, 2019 - nature.com
Base editing tools for cytosine to thymine (C–T) conversion enable genome manipulation at
single base-pair resolution with high efficiency. Available base editors (BEs) for C–T …
single base-pair resolution with high efficiency. Available base editors (BEs) for C–T …
Identification of topological surface state in PdTe2 superconductor by angle-resolved photoemission spectroscopy
High-resolution angle-resolved photoemission measurements are carried out on transition
metal dichalcogenide PdTe 2 that is a superconductor with a T c at 1.7 K. Combined with …
metal dichalcogenide PdTe 2 that is a superconductor with a T c at 1.7 K. Combined with …
[HTML][HTML] TadA reprogramming to generate potent miniature base editors with high precision
Although miniature CRISPR-Cas12f systems were recently developed, the editing efficacy
and targeting range of derived miniature cytosine and adenine base editors (miniCBEs and …
and targeting range of derived miniature cytosine and adenine base editors (miniCBEs and …
[HTML][HTML] TadA orthologs enable both cytosine and adenine editing of base editors
Cytidine and adenosine deaminases are required for cytosine and adenine editing of base
editors respectively, and no single deaminase could enable concurrent and comparable …
editors respectively, and no single deaminase could enable concurrent and comparable …
Reversal of Social Recognition Deficit in Adult Mice with MECP2 Duplication via Normalization of MeCP2 in the Medial Prefrontal Cortex
Methyl-CpG binding protein 2 (MeCP2) is a basic nuclear protein involved in the regulation
of gene expression and microRNA processing. Duplication of MECP2-containing genomic …
of gene expression and microRNA processing. Duplication of MECP2-containing genomic …
[HTML][HTML] Regulation of mRNA splicing by MeCP2 via epigenetic modifications in the brain
TL Cheng, J Chen, H Wan, B Tang, W Tian, L Liao… - Scientific reports, 2017 - nature.com
Mutations of X-linked gene Methyl CpG binding protein 2 (MECP2) are the major causes of
Rett syndrome (RTT), a severe neurodevelopmental disorder. Duplications of MECP2-…
Rett syndrome (RTT), a severe neurodevelopmental disorder. Duplications of MECP2-…