Little is known about the biological function of histone deacetylase 11 (HDAC11), which is
the lone class IV HDAC. Here, we demonstrate that deletion of HDAC11 in mice stimulates …

Phagocytosis of apoptotic cells requires recognition of cell corpses followed by internalization
and enclosure within plasma membrane-derived phagosomes. Phagosomes undergo …

Improving the thermal stability of biologics, including vaccines, is critical to reduce the economic
costs and health risks associated with the cold chain. Here, we designed a versatile, safe…

Histone deacetylase 5 (HDAC5) and HDAC9 are class IIa HDACs that function as signal-responsive
repressors of the epigenetic program for pathological cardiomyocyte hypertrophy. …

N-myristoylation on glycine is an irreversible modification that has long been recognized to
govern protein localization and function. In contrast, the biological roles of lysine …

During apoptosis, the dying cell activates an intrinsic mechanism that quickly dismantles
itself. The apoptotic cell corpses are then recognized and removed by neighboring cells or …

Pulmonary hypertension (PH) is associated with structural remodeling of pulmonary arteries
(PAs) because of excessive proliferation of fibroblasts, endothelial cells, and smooth muscle …

The Eph family of tyrosine kinase receptors and their ligands, the ephrins, participates in the
regulation of a wide variety of biological functions under normal and pathological conditions…

Topographic mapping of axon terminals is a general principle of neural architecture that
underlies the interconnections among many neural structures. The Eph family tyrosine kinase …

Class I histone deacetylase (HDAC) inhibitors block hypertrophy and fibrosis of the heart by
suppressing pathological signaling and gene expression programs in cardiac myocytes and …