User profiles for Tianmu Wen
 | Tianmu WenSMPH, University of Wisconsin - Madison Verified email at wisc.edu Cited by 157 |
The nuclear phosphoinositide response to stress
Accumulating evidence reveals that nuclear phosphoinositides (PIs) serve as central signaling
hubs that control a multitude of nuclear processes by regulating the activity of nuclear …
hubs that control a multitude of nuclear processes by regulating the activity of nuclear …
A p53–phosphoinositide signalosome regulates nuclear AKT activation
The tumour suppressor p53 and PI3K–AKT pathways have fundamental roles in the regulation
of cell growth and apoptosis, and are frequently mutated in cancer. Here, we show that …
of cell growth and apoptosis, and are frequently mutated in cancer. Here, we show that …
[HTML][HTML] Regulation of Phosphoinositide Signaling by Scaffolds at Cytoplasmic Membranes
Cytoplasmic phosphoinositides (PI) are critical regulators of the membrane–cytosol interface
that control a myriad of cellular functions despite their low abundance among phospholipids…
that control a myriad of cellular functions despite their low abundance among phospholipids…
Phosphatidylinositol 3-kinase signalling is spatially organized at endosomal compartments by microtubule-associated protein 4
The canonical model of agonist-stimulated phosphatidylinositol 3-kinase (PI3K)–Akt signalling
proposes that PI3K is activated at the plasma membrane, where receptors are activated …
proposes that PI3K is activated at the plasma membrane, where receptors are activated …
[HTML][HTML] The specificity of EGF-stimulated IQGAP1 scaffold towards the PI3K-Akt pathway is defined by the IQ3 motif
Epidermal growth factor receptor (EGFR) and its downstream phosphoinositide 3-kinase (PI3K)
pathway are commonly deregulated in cancer. Recently, we have shown that the IQ motif…
pathway are commonly deregulated in cancer. Recently, we have shown that the IQ motif…
[HTML][HTML] Regulation of Cell Adhesion and Migration via Microtubule Cytoskeleton Organization, Cell Polarity, and Phosphoinositide Signaling
The capacity for cancer cells to metastasize to distant organs depends on their ability to
execute the carefully choreographed processes of cell adhesion and migration. As most human …
execute the carefully choreographed processes of cell adhesion and migration. As most human …
Nuclear phosphoinositide signaling promotes YAP/TAZ-TEAD transcriptional activity in breast cancer
The Hippo pathway effectors Yes-associated protein 1 (YAP) and its homolog TAZ are
transcriptional coactivators that control gene expression by binding to TEA domain (TEAD) family …
transcriptional coactivators that control gene expression by binding to TEA domain (TEAD) family …
Assessing in situ phosphoinositide–protein interactions through fluorescence proximity ligation assay in cultured cells
Proximity ligation assay (PLA) is a well-established method for detecting in situ interactions
between two epitopes with high resolution and specificity. Notably, PLA is not only a robust …
between two epitopes with high resolution and specificity. Notably, PLA is not only a robust …
Regulation of NRF2 by Phosphoinositides and Small Heat Shock Proteins
Reactive oxygen species (ROS) are generated by aerobic metabolism, and their deleterious
effects are buffered by the cellular antioxidant response, which prevents oxidative stress. …
effects are buffered by the cellular antioxidant response, which prevents oxidative stress. …
Abstract A09: Therapeutic targeting of TSC2-deficient cells with Methotrexate: Results of a drug repurposing screen
…, H Lam, A Valvezan, R Huang, M Xia, T Wen… - Clinical Cancer …, 2017 - AACR
Tuberous sclerosis complex (TSC) is a multisystem disorder that affects multiple organ
systems, including tumors of the brain, heart, kidney, skin and lung. TSC is caused by germline …
systems, including tumors of the brain, heart, kidney, skin and lung. TSC is caused by germline …