DNA double-strand break (DSB) repair interferes with ongoing cellular processes, including
replication and transcription. Although the process of replication stalling upon collision of …

Faithful DNA repair is essential to avoid chromosomal rearrangements and promote
genome integrity. Nuclear organization has emerged as a key parameter in the formation of …

DNA double-strand breaks (DSBs) at RNA polymerase II (RNAPII) transcribed genes lead to
inhibition of transcription. The DNA-dependent protein kinase (DNA-PK) complex plays a …

Exosomes are small extracellular vesicles (sEVs), playing a crucial role in the intercellular
communication in physiological as well as pathological processes. Here, we aimed to study …

In Drosophila and several other metazoan organisms, there are two genes that encode related
but distinct homologs of ADA2-type transcriptional adaptors. Here we describe mutations …

Recently, it has been described that programmed cell death protein 1 (PD-1) overexpressing
melanoma cells are highly aggressive. However, until now it has not been defined which …

In eukaryotic cells, each process, in which DNA is involved, should take place in the context
of a chromatin structure. DNA double-strand breaks (DSBs) are one of the most deleterious …

Simple Summary The invasive nature of brain tumours, particularly glioblastoma, severely
limits its therapy. Matrix-metalloproteinases (MMPs), enzymes involved in the degradation of …

The histone acetyltransferase (HAT) Gcn5 plays a role in chromatin structure and gene
expression regulation as a catalytic component of multiprotein complexes, some of which also …

Breast cancer is the most frequent cancer with a high fatality rate amongst women worldwide.
Diagnosing at an early stage is challenging, and due to the limitations of the currently used …