Background Peripartum cardiomyopathy shares some clinical features with idiopathic dilated
cardiomyopathy, a disorder caused by mutations in more than 40 genes, including TTN, …

More than 90% of drugs with preclinical activity fail in human trials, largely due to insufficient
efficacy. We hypothesized that adequately powered trials of patient-derived xenografts (PDX…

Mesenchymal stem/progenitor cells are essential for tissue development and repair throughout
life, but how they are maintained under chronic differentiation pressure is not known. …

Single-cell sequencing technologies have revealed an unexpectedly broad repertoire of
cells required to mediate complex functions in multicellular organisms. Despite the multiple …

Human thermogenic adipose tissue mitigates metabolic disease, thus raising much interest
in understanding its development and function. Here, we show that human thermogenic …

Patients with angioimmunoblastic T-cell lymphoma (AITL) and other peripheral T-cell
lymphomas that harbor features of follicular helper T (T FH ) cells have a very poor prognosis. …

Pregnancy is a physiological state of continuous adaptation to changing maternal and fetal
nutritional needs, including a reduction of maternal insulin sensitivity allowing for …

AMPK is a master regulator of cellular metabolism that exerts either oncogenic or tumor
suppressor activity depending on context. Here, we report that the specific AMPK agonist …

Obesity and type 2 diabetes are associated with disturbances in insulin-regulated glucose
and lipid fluxes and severe comorbidities including cardiovascular disease and steatohepatitis…

Objective Perivascular adipose tissue depots around the aorta are regionally distinct and
have specific functional properties. Thoracic aorta perivascular adipose tissue (tPVAT) …