The ability to respond to differential levels of oxygen is important to all respiring cells. The
response to oxygen deficiency, or hypoxia, takes many forms and ranges from systemic …

To identify functions of the IKKα subunit of IκB kinase that require catalytic activity, we generated
an Ikkα AA knockin allele containing alanines instead of serines in the activation loop. …

The hexosamine biosynthetic pathway elevates posttranslational addition of O-linked β-N-acetylglucosamine
(O-GlcNAc) on intracellular proteins. Cancer cells elevate total O-…

Adaptation to hypoxia is a critical step in tumor progression and is, in part, regulated by the
transcription factor hypoxia-inducible factor-1α (HIF-1α). Xenograft models have been …

The CCAAT/enhancer binding proteins (C/EBPs) are differentially expressed throughout
mammary gland development and interact with binding sites within the promoter of a milk …

Introduction Overexpression of the oxygen-responsive transcription factor hypoxia-inducible
factor 1α (HIF-1α) correlates with poor prognosis in breast cancer patients. The mouse …

Background Hypoxia-inducible factors (HIFs) are well-established mediators of tumor growth,
the epithelial to mesenchymal transition (EMT) and metastasis. In several types of solid …

Cancers exhibit altered metabolism characterized by increased glucose and glutamine uptake.
The hexosamine biosynthetic pathway (HBP) uses glucose and glutamine, and directly …

Deletion of the transcription factor CCAAT/enhancer binding protein (C/EBP)β results in a
severe inhibition of lobuloalveolar development in the mouse mammary gland. Because …

Introduction In breast cancer, distinct expression profiles of microRNAs (miRNAs) have been
associated with molecular subgroups and clinicopathological characteristics, implicating a …