Partial or complete loss-of-function variants in SCN5A are the most common genetic cause
of the arrhythmia disorder Brugada syndrome (BrS1). However, the pathogenicity of SCN5A …

Background: Variants in ion channel genes have classically been studied in low throughput
by patch clamping. Deep mutational scanning is a complementary approach that can …

Moving toward the electronic health record increases the quality of information gathered.
However, nurses argue that the electronic health record is an added burden. The aim of this …

The cardiac sodium ion channel (Na V 1.5) is a protein with four domains (DI-DIV), each with
six transmembrane segments. Its opening and subsequent inactivation results in the brief …

Variants in ion channel genes have classically been studied in low-throughput by patch
clamping. Deep Mutational Scanning (DMS) is a complementary approach that can …

Partial or complete loss-of-function variants in SCN5A are the most common genetic cause
of the arrhythmia disorder Brugada syndrome (BrS1). However, the pathogenicity of SCN5A …

Hereditary hemochromatosis (HH) is an autosomal recessive disorder of excess iron
absorption. The most common form, HH1, is caused by loss of function variants in HFE. HFE …

As California competes for jobs in an increasingly competitive global economy, the state faces
a looming shortage of highly educated workers (PPIC, 2012). For a variety of reasons, the …

Despite the expressed need for high-quality science education, very little research has been
conducted on what middle school science learning opportunities look like in practice. This …

As 21st Century scholars emphasize the importance of globalization, cross-cultural climates
that foster genuine engagement with race and gender are becoming increasingly significant …