[PDF][PDF] Impeding DNA break repair enables oocyte quality control

…, M Sapre, M Nguyen, A Tham, BW Van, TYH Chng… - Molecular cell, 2018 - cell.com
Oocyte quality control culls eggs with defects in meiosis. In mouse, oocyte death can be
triggered by defects in chromosome synapsis and recombination, which involve repair of DNA …

Oncogenic activation of the STAT3 pathway drives PD-L1 expression in natural killer/T-cell lymphoma

…, NF Grigoropoulos, SB Ng, WJ Chng… - Blood, The Journal …, 2018 - ashpublications.org
Mature T-cell lymphomas, including peripheral T-cell lymphoma (PTCL) and extranodal NK/T-cell
lymphoma (NKTL), represent a heterogeneous group of non-Hodgkin lymphomas with …

Type II enteropathy‐associated T‐cell lymphoma: a multicenter analysis from the Asia Lymphoma Study Group

…, SB Ng, T Tang, YH Ko, WJ Chng… - American journal of …, 2012 - Wiley Online Library
YH Ko diagnosed the cases, analyzed the data, and approved the article. WJ Chng
treated the patients, analyzed the data, and approved the article. ST Lim treated the patients, …

Genetic risk of extranodal natural killer T-cell lymphoma: a genome-wide association study

…, F Mohamad, SY Tan, BT Teh, SB Ng, WJ Chng… - The Lancet …, 2016 - thelancet.com
Background Extranodal natural killer T-cell lymphoma (NKTCL), nasal type, is a rare and
aggressive malignancy that occurs predominantly in Asian and Latin American populations. …

Genetic risk of extranodal natural killer T-cell lymphoma: a genome-wide association study in multiple populations

…, Y Liu, F Zhang, Y Feng, H Rao, WJ Chng… - The Lancet …, 2020 - thelancet.com
Background Extranodal natural killer T-cell lymphoma (NKTCL; nasal type) is an aggressive
malignancy with a particularly high prevalence in Asian and Latin American populations. …

Recurrent</i> PD-L1<//i> Structural Rearrangements in Natural Killer/T Cell Lymphoma Patients with Complete Response to PD-1 Blockade Therapy

…, TSY Chan, SB Ng, YL Kwong, W Hwang, WJ Chng… - 2018 - lirias.kuleuven.be
This study aims to identify recurrent genetic alterations in relapsed or refractory (RR)
naturalkiller/T-cell lymphoma (NKTL) patients who have achieved complete response (CR) with …

Counterproductive effects of anti-CD38 and checkpoint inhibitor for the treatment of NK/T cell lymphoma

…, KJ Puan, LW Wang, J Lim, KP Tan, WJ Chng… - Frontiers in …, 2024 - frontiersin.org
Introduction Natural killer/T cell lymphoma (NKTL) is an aggressive malignancy associated
with poor prognosis. This is largely due to limited treatment options, especially for relapsed …

Global prevalence and clinical characteristics of metabolic-associated fatty liver disease: a meta-analysis and systematic review of 10 739 607 individuals

…, M Muthiah, M Eslam, CH Ng - The Journal of …, 2022 - academic.oup.com
Background and Aims Metabolic-associated fatty liver disease (MAFLD) was proposed as a
better definition of nonalcoholic fatty liver disease (NAFLD) to encompass the metabolic …

Radioembolisation with Y90-resin microspheres followed by nivolumab for advanced hepatocellular carcinoma (CA 209-678): a single arm, single centre, phase 2 trial

D Tai, K Loke, A Gogna, NA Kaya, SH Tan… - The Lancet …, 2021 - thelancet.com
Background Therapeutic synergism between radiotherapy and immune checkpoint blockade
has been observed in preclinical models of hepatocellular carcinoma. We aimed to study …

Enteropathy-associated T cell lymphoma subtypes are characterized by loss of function of SETD2

AB Moffitt, SL Ondrejka, M McKinney… - Journal of Experimental …, 2017 - rupress.org
Enteropathy-associated T cell lymphoma (EATL) is a lethal, and the most common, neoplastic
complication of celiac disease. Here, we defined the genetic landscape of EATL through …