Previous reports indicate that the midbrain periaqueductal gray and the central nucleus of
the amygdala are interconnected but the organization of these projections has not been …

Background Effective medical therapies are lacking for the treatment of neurofibromatosis
type 1–related plexiform neurofibromas, which are characterized by elevated RAS–mitogen-…

Children with neurofibromatosis type 1 (NF1) are predisposed to juvenile myelomonocytic
leukemia (JMML), an aggressive myeloproliferative neoplasm (MPN) that is refractory to …

Neurofibromatosis type 1 (Nf1) mutation predisposes to benign peripheral nerve (glial) tumors
called neurofibromas. The point(s) in development when Nf1 loss promotes neurofibroma …

Schwannomas are peripheral nerve tumors that typically have mutations in the NF2 tumor
suppressor gene. We compared cultured schwannoma cells with Schwann cells from normal …

The midbrain periaqueductal gray (PAG) participates in diverse functions such as analgesia,
autonomic regulation, sexual behavior, and defense/escape responses. Anatomical studies …

Neurofibromatosis type 1 (NF1) is a common genetic disease that predisposes 30–50 % of
affected individuals to develop plexiform neurofibromas. We found that macrophage …

We describe a key role for the CD44 transmembrane glycoprotein in Schwann cell–neuron
interactions. CD44 proteins have been implicated in cell adhesion and in the presentation of …

Approaches to successful cell transplantation therapies for the injured brain involve selecting
the appropriate neural progenitor type and optimizing the efficiency of the cell engraftment. …

Benign neurofibromas and malignant peripheral nerve sheath tumors are serious complications
of neurofibromatosis type 1. The epidermal growth factor receptor is not expressed by …