[HTML][HTML] PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study
Background Statin treatment and variants in the gene encoding HMG-CoA reductase are
associated with reductions in both the concentration of LDL cholesterol and the risk of coronary …
associated with reductions in both the concentration of LDL cholesterol and the risk of coronary …
Sex differences in body fat distribution are related to sex differences in serum leptin and adiponectin
It is debated whether sex differences in adiponectin and leptin are due to sex differences in
body fat distribution. In this cross-sectional analysis of the Netherlands Epidemiology of …
body fat distribution. In this cross-sectional analysis of the Netherlands Epidemiology of …
CETP (cholesteryl ester transfer protein) concentration: a genome-wide association study followed by Mendelian randomization on coronary artery disease
Background: We aimed to identify independent genetic determinants of circulating CETP (cholesteryl
ester transfer protein) to assess causal effects of variation in CETP concentration …
ester transfer protein) to assess causal effects of variation in CETP concentration …
Body fat, especially visceral fat, is associated with electrocardiographic measures of sympathetic activation
S Hillebrand, R de Mutsert, T Christen, AC Maan… - …, 2014 - Wiley Online Library
Objective Obesity is associated with sympathetic activation, but the role of different fat
depots is unclear. The association between body fat, specifically visceral fat, and …
depots is unclear. The association between body fat, specifically visceral fat, and …
[HTML][HTML] Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9
…, H Snieder, Lifelines Cohort authors, T Christen… - BMC cardiovascular …, 2019 - Springer
Background We characterised the phenotypic consequence of genetic variation at the PCSK9
locus and compared findings with recent trials of pharmacological inhibitors of PCSK9. …
locus and compared findings with recent trials of pharmacological inhibitors of PCSK9. …
The role of inflammation in the association between overall and visceral adiposity and subclinical atherosclerosis
Background and aims Inflammation may underlie the association between obesity, atherosclerosis
and cardiovascular disease. We investigated to what extent markers of inflammation …
and cardiovascular disease. We investigated to what extent markers of inflammation …
The real deal: using cytochalasin B in sonodynamic therapy to preferentially damage leukemia cells
…, G Yu, V Wong, C Acquafondata, T Christen… - Anticancer …, 2014 - ar.iiarjournals.org
Background/Aim: Sonodynamic therapy (SDT) is a form of ultrasound therapy in which
chemotherapeutic agents known as sonosensitizers are administered to increase the efficacy of …
chemotherapeutic agents known as sonosensitizers are administered to increase the efficacy of …
[HTML][HTML] Mendelian randomization study of the relation between adiponectin and heart function, unravelling the paradox
High adiponectin concentrations are generally regarded as beneficial with regard to
cardiometabolic health, but have been paradoxically associated with increased cardiovascular …
cardiometabolic health, but have been paradoxically associated with increased cardiovascular …
Mendelian randomization analysis of cholesteryl ester transfer protein and subclinical atherosclerosis: A population-based study
T Christen, S Trompet, R Noordam, LL Blauw… - Journal of clinical …, 2018 - Elsevier
Background Several trials to prevent cardiovascular disease by inhibiting cholesteryl ester
transfer protein (CETP) have failed, except Randomized EValuation of the Effects of …
transfer protein (CETP) have failed, except Randomized EValuation of the Effects of …
The role of C-reactive protein, adiponectin and leptin in the association between abdominal adiposity and insulin resistance in middle-aged individuals
…, V Boersma, I Verkouter, S le Cessie, T Christen… - Nutrition, Metabolism …, 2020 - Elsevier
Background and aims In the present study, we assessed the extent of mediation by low-grade
systemic inflammation and adipokines in the association between abdominal adiposity …
systemic inflammation and adipokines in the association between abdominal adiposity …