User profiles for Tim D. Spector
 | Tim D SpectorGuys and St Thomas Hospital NHS Trust, Kings College London Verified email at kcl.ac.uk Cited by 255938 |
[PDF][PDF] Global analysis of DNA methylation variation in adipose tissue from twins reveals links to disease-associated variants in distal regulatory elements
…, S Potter, J Sandling, N Soranzo, TD Spector… - The American Journal of …, 2013 - cell.com
Epigenetic modifications such as DNA methylation play a key role in gene regulation and
disease susceptibility. However, little is known about the genome-wide frequency, localization, …
disease susceptibility. However, little is known about the genome-wide frequency, localization, …
[HTML][HTML] Risk of COVID-19 among front-line health-care workers and the general community: a prospective cohort study
Background Data for front-line health-care workers and risk of COVID-19 are limited. We
sought to assess risk of COVID-19 among front-line health-care workers compared with the …
sought to assess risk of COVID-19 among front-line health-care workers compared with the …
Biological, clinical and population relevance of 95 loci for blood lipids
…, T Tanaka, I Surakka, HM Stringham, TD Spector… - Nature, 2010 - nature.com
Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density
lipoprotein cholesterol and triglycerides are among the most important risk factors for …
lipoprotein cholesterol and triglycerides are among the most important risk factors for …
Osteoarthritis: new insights. Part 1: the disease and its risk factors
…, MF Sowers, T McAlindon, TD Spector… - Annals of internal …, 2000 - acpjournals.org
Osteoarthritis is the most common form of arthritis, affecting millions of people in the United
States. It is a complex disease whose etiology bridges biomechanics and biochemistry. …
States. It is a complex disease whose etiology bridges biomechanics and biochemistry. …
Epigenetic differences arise during the lifetime of monozygotic twins
…, A Vaag, Z Stephan, TD Spector… - Proceedings of the …, 2005 - National Acad Sciences
Monozygous twins share a common genotype. However, most monozygotic twin pairs are
not identical; several types of phenotypic discordance may be observed, such as differences …
not identical; several types of phenotypic discordance may be observed, such as differences …
[HTML][HTML] Vaccine side-effects and SARS-CoV-2 infection after vaccination in users of the COVID Symptom Study app in the UK: a prospective observational study
Background The Pfizer-BioNTech (BNT162b2) and the Oxford-AstraZeneca (ChAdOx1
nCoV-19) COVID-19 vaccines have shown excellent safety and efficacy in phase 3 trials. We …
nCoV-19) COVID-19 vaccines have shown excellent safety and efficacy in phase 3 trials. We …
[HTML][HTML] Real-time tracking of self-reported symptoms to predict potential COVID-19
A total of 2,618,862 participants reported their potential symptoms of COVID-19 on a
smartphone-based app. Among the 18,401 who had undergone a SARS-CoV-2 test, the proportion …
smartphone-based app. Among the 18,401 who had undergone a SARS-CoV-2 test, the proportion …
[HTML][HTML] Risk factors and disease profile of post-vaccination SARS-CoV-2 infection in UK users of the COVID Symptom Study app: a prospective, community-based …
Background COVID-19 vaccines show excellent efficacy in clinical trials and effectiveness
in real-world data, but some people still become infected with SARS-CoV-2 after vaccination. …
in real-world data, but some people still become infected with SARS-CoV-2 after vaccination. …
[HTML][HTML] The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis
…, S Ortolani, JE Badurski, TD Spector… - … England Journal of …, 2004 - Mass Medical Soc
Background Osteoporotic structural damage and bone fragility result from reduced bone
formation and increased bone resorption. In a phase 2 clinical trial, strontium ranelate, an orally …
formation and increased bone resorption. In a phase 2 clinical trial, strontium ranelate, an orally …
Large-scale association analyses identify host factors influencing human gut microbiome composition
To study the effect of host genetics on gut microbiome composition, the MiBioGen consortium
curated and analyzed genome-wide genotypes and 16S fecal microbiome data from …
curated and analyzed genome-wide genotypes and 16S fecal microbiome data from …