The X-linked Foxp3 is a member of the forkhead/winged helix transcription factor family.
Germline mutations cause lethal autoimmune diseases in males. Serendipitously, we observed …

We are beginning to appreciate the increasing complexity of mammalian gene structure. A
phenomenon that adds an important dimension to this complexity is the use of alternative …

Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of the Polycomb-repressive
complex 2 (PRC2) that represses gene transcription through histone H3 lysine 27 trimethylation (…

Purpose: Genetic alterations were previously identified in normal epithelia adjacent to invasive
cancers. The aim of this study was to determine DNA methylation in histologically normal …

Epigenetic alterations of the genome such as DNA promoter methylation and chromatin
remodeling play an important role in tumorigenesis. Recent findings indicate epigenetic …

Purpose: This study evaluated the effects of black raspberries (BRBs) on biomarkers of
tumor development in the human colon and rectum including methylation of relevant tumor …

In breast cancer and normal estrogen target tissues, estrogen receptor-α (ERα) signaling
results in the establishment of spatiotemporal patterns of gene expression. Whereas primary …

The c-myc proto-oncogene encodes a transcription factor, c-Myc, which is deregulated and/or
overexpressed in many human cancers. Despite c-Myc's importance, the identity of Myc-…

Ovarian cancer is the most lethal of all gynecologic neoplasms. Early-stage malignancy is
frequently asymptomatic and difficult to detect and thus, by the time of diagnosis, most women …

Hypermethylation of 5′-cytosine-guanosine islands of tumor suppressor genes resulting in
their silencing has been proposed to be a hallmark of various tumors. Modulation of DNA …