User profiles for Tim Lohoff
Tim LohoffPhD Student, University of Cambridge Verified email at cam.ac.uk Cited by 857 |
Multi-omics profiling of mouse gastrulation at single-cell resolution
Formation of the three primary germ layers during gastrulation is an essential step in the
establishment of the vertebrate body plan and is associated with major transcriptional changes …
establishment of the vertebrate body plan and is associated with major transcriptional changes …
Highly multiplexed spatially resolved gene expression profiling of mouse organogenesis
Transcriptional and epigenetic profiling of single-cells has advanced our knowledge of the
molecular bases of gastrulation and early organogenesis. However, current approaches rely …
molecular bases of gastrulation and early organogenesis. However, current approaches rely …
[PDF][PDF] Complementary activity of ETV5, RBPJ, and TCF3 drives formative transition from naive pluripotency
The gene regulatory network (GRN) of naive mouse embryonic stem cells (ESCs) must be
reconfigured to enable lineage commitment. TCF3 sanctions rewiring by suppressing …
reconfigured to enable lineage commitment. TCF3 sanctions rewiring by suppressing …
[HTML][HTML] Single-cell multi-omics profiling links dynamic DNA methylation to cell fate decisions during mouse early organogenesis
Background Perturbation of DNA methyltransferases (DNMTs) and of the active DNA
demethylation pathway via ten-eleven translocation (TET) methylcytosine dioxygenases results in …
demethylation pathway via ten-eleven translocation (TET) methylcytosine dioxygenases results in …
The circadian clock modulates global daily cycles of mRNA ribosome loading
Circadian control of gene expression is well characterized at the transcriptional level, but
little is known about diel or circadian control of translation. Genome-wide translation state …
little is known about diel or circadian control of translation. Genome-wide translation state …
Decoding gene regulation in the mouse embryo using single-cell multi-omics
Following gastrulation, the three primary germ layers develop into the major organs in a
process known as organogenesis. Single-cell RNA sequencing has enabled the profiling of the …
process known as organogenesis. Single-cell RNA sequencing has enabled the profiling of the …
Metabolic control of DNA methylation in naive pluripotent cells
Naive epiblast and embryonic stem cells (ESCs) give rise to all cells of adults. Such developmental
plasticity is associated with genome hypomethylation. Here, we show that LIF–Stat3 …
plasticity is associated with genome hypomethylation. Here, we show that LIF–Stat3 …
Inactivation of cancer mutations utilizing CRISPR/Cas9
C Gebler, T Lohoff… - Journal of the …, 2017 - academic.oup.com
Although whole-genome sequencing has uncovered a large number of mutations that drive
tumorigenesis, functional ratification for most mutations remains sparse. Here, we present an …
tumorigenesis, functional ratification for most mutations remains sparse. Here, we present an …
[PDF][PDF] Distinct molecular trajectories converge to induce naive pluripotency
Understanding how cell identity transitions occur and whether there are multiple paths
between the same beginning and end states are questions of wide interest. Here we show that …
between the same beginning and end states are questions of wide interest. Here we show that …
Investing in vision: Innovation in retinal therapeutics and the influence on venture capital investment
D Hristodorov, T Lohoff, N Luneborg, GJ Mulder… - Progress in Retinal and …, 2024 - Elsevier
Since the groundbreaking approval of the first anti-VEGF therapy in 2004, the retinal therapeutics
field has undergone a remarkable transformation, witnessing a surge in novel, disease-…
field has undergone a remarkable transformation, witnessing a surge in novel, disease-…