User profiles for Tim Lohoff

Tim Lohoff

PhD Student, University of Cambridge
Verified email at cam.ac.uk
Cited by 857

Multi-omics profiling of mouse gastrulation at single-cell resolution

…, CA Kapourani, I Imaz-Rosshandler, T Lohoff… - Nature, 2019 - nature.com
Formation of the three primary germ layers during gastrulation is an essential step in the
establishment of the vertebrate body plan and is associated with major transcriptional changes …

Highly multiplexed spatially resolved gene expression profiling of mouse organogenesis

T Lohoff, S Ghazanfar, A Missarova, N Koulena… - BioRxiv, 2020 - biorxiv.org
Transcriptional and epigenetic profiling of single-cells has advanced our knowledge of the
molecular bases of gastrulation and early organogenesis. However, current approaches rely …

[PDF][PDF] Complementary activity of ETV5, RBPJ, and TCF3 drives formative transition from naive pluripotency

T Kalkan, S Bornelöv, C Mulas, E Diamanti, T Lohoff… - Cell stem cell, 2019 - cell.com
The gene regulatory network (GRN) of naive mouse embryonic stem cells (ESCs) must be
reconfigured to enable lineage commitment. TCF3 sanctions rewiring by suppressing …

[HTML][HTML] Single-cell multi-omics profiling links dynamic DNA methylation to cell fate decisions during mouse early organogenesis

SJ Clark, R Argelaguet, T Lohoff, F Krueger, D Drage… - Genome biology, 2022 - Springer
Background Perturbation of DNA methyltransferases (DNMTs) and of the active DNA
demethylation pathway via ten-eleven translocation (TET) methylcytosine dioxygenases results in …

The circadian clock modulates global daily cycles of mRNA ribosome loading

A Missra, B Ernest, T Lohoff, Q Jia, J Satterlee… - The Plant …, 2015 - academic.oup.com
Circadian control of gene expression is well characterized at the transcriptional level, but
little is known about diel or circadian control of translation. Genome-wide translation state …

Decoding gene regulation in the mouse embryo using single-cell multi-omics

R Argelaguet, T Lohoff, JG Li, A Nakhuda, D Drage… - BioRxiv, 2022 - biorxiv.org
Following gastrulation, the three primary germ layers develop into the major organs in a
process known as organogenesis. Single-cell RNA sequencing has enabled the profiling of the …

Metabolic control of DNA methylation in naive pluripotent cells

…, V Guerineau, D Touboul, GG Stirparo, T Lohoff… - Nature …, 2021 - nature.com
Naive epiblast and embryonic stem cells (ESCs) give rise to all cells of adults. Such developmental
plasticity is associated with genome hypomethylation. Here, we show that LIF–Stat3 …

Inactivation of cancer mutations utilizing CRISPR/Cas9

C Gebler, T Lohoff… - Journal of the …, 2017 - academic.oup.com
Although whole-genome sequencing has uncovered a large number of mutations that drive
tumorigenesis, functional ratification for most mutations remains sparse. Here, we present an …

[PDF][PDF] Distinct molecular trajectories converge to induce naive pluripotency

HT Stuart, GG Stirparo, T Lohoff, LE Bates, M Kinoshita… - Cell Stem Cell, 2019 - cell.com
Understanding how cell identity transitions occur and whether there are multiple paths
between the same beginning and end states are questions of wide interest. Here we show that …

Investing in vision: Innovation in retinal therapeutics and the influence on venture capital investment

D Hristodorov, T Lohoff, N Luneborg, GJ Mulder… - Progress in Retinal and …, 2024 - Elsevier
Since the groundbreaking approval of the first anti-VEGF therapy in 2004, the retinal therapeutics
field has undergone a remarkable transformation, witnessing a surge in novel, disease-…